Document Type

Journal Article

Publication Title

Nutrients

Volume

14

Issue

5

PubMed ID

35268067

Publisher

MDPI

School

School of Medical and Health Sciences

Funders

Tai’an Science and Technology Innovation Development Project (No. 2020NS191), Young Taishan Scholars Program of Shandong Province of China (No. tsqn20161046), Academic Promotion Program of Shandong First Medical University (2019RC010), Shandong Province Higher Educational Young and Innovation Technology Supporting Program (2019KJL004).

Comments

Cong, R., Zhang, X., Song, Z., Chen, S., Liu, G., Liu, Y., ... & Xu, X. (2022). Assessing the Causal Effects of Adipokines on Uric Acid and Gout: A Two-Sample Mendelian Randomization Study. Nutrients, 14(5), 1091. https://doi.org/10.3390/nu14051091

Abstract

Previous observational studies have highlighted associations between adipokines and hyperuricemia, as well as gout, but the causality and direction of these associations are not clear. Therefore, we attempted to assess whether there are causal effects of specific adipokines (such as adiponectin (ADP) and soluble leptin receptors (sOB-R)) on uric acid (UA) or gout in a two-sample Mendelian randomization (MR) analysis, based on summary statistics from large genome-wide association studies. The inverse-variance weighted (IVW) method was performed as the primary analysis. Sensitivity analyses (including MR-Egger regression, weighted median, penalized weighted median, and MR pleiotropy residual sum and outlier methods) were also performed, to ensure reliable results. In the IVW models, no causal effect was found for sOB-R (odds ratios (OR), 1.002; 95% confidence intervals (CI), 0.999–1.004; p = 0.274) on UA, or ADP (OR, 1.198; 95% CI, 0.865–1.659; p = 0.277) or sOB-R (OR, 0.988; 95% CI, 0.940–1.037; p = 0.616) on gout. The results were confirmed in sensitivity analyses. There was no notable directional pleiotropy or heterogeneity. This study suggests that these specific adipokines may not play causal roles in UA or gout development.

DOI

10.3390/nu14051091

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Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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