Document Type
Journal Article
Publication Title
Nutrition, Metabolism and Cardiovascular Diseases
Volume
32
Issue
4
First Page
1001
Last Page
1009
PubMed ID
35086766
Publisher
Elsevier
School
School of Medical and Health Sciences / Centre for Precision Health
RAS ID
42776
Funders
Application and Evaluation of Active Health Cloud Platform in China, National Key R&D Program of China (2018YFC2000704), China-Australian Collaborative Grant (NSFC 81561128020-NHMRC APP1112767).
Grant Number
81561128020 -NHMRC APP1112767
Grant Link
http://purl.org/au-research/grants/nhmrc/1112767
Abstract
Background and aims: Observational studies showed that coronavirus disease (2019) (COVID-19) attacks universally and its most menacing progression uniquely endangers the elderly with cardiovascular disease (CVD). The causal association between COVID-19 infection or its severity and susceptibility of atrial fibrillation (AF) remains unknown. Methods and results: The bidirectional causal relationship between COVID-19 (including COVID-19, hospitalized COVID-19 compared with not hospitalized COVID-19, hospitalized COVID-19 compared with the general population, and severe COVID-19) and AF are determined by using two-sample Mendelian randomization (MR) analysis. Genetically predicted severe COVID-19 was not significantly associated with the risk of AF [odds ratio (OR), 1.037; 95% confidence interval (CI), 1.005–1.071; P = 0.023, q = 0.115]. In addition, genetically predicted AF was also not causally associated with severe COVID-19 (OR, 0.993; 95% CI, 0.888–1.111; P = 0.905, q = 0.905). There was no evidence to support the association between genetically determined COVID-19 and the risk of AF (OR, 1.111; 95% CI, 0.971–1.272; P = 0.127, q = 0.318), and vice versa (OR, 1.016; 95% CI, 0.976–1.058; P = 0.430, q = 0.851). Besides, no significant association was observed for hospitalized COVID-19 with AF. MR-Egger analysis indicated no evidence of directional pleiotropy. Conclusion: Overall, this MR study provides no clear evidence that COVID-19 is causally associated with the risk of AF.
DOI
10.1016/j.numecd.2021.11.010
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Research Themes
Health
Priority Areas
Multidisciplinary biological approaches to personalised disease diagnosis, prognosis and management
Comments
Zhang, X., Wang, B., Geng, T., Liu, D., Tian, Q., Meng, X., ... & Wang, B. (2022). Causal associations between COVID-19 and Atrial Fibrillation: A bidirectional Mendelian randomization study. Nutrition, Metabolism and Cardiovascular Diseases, 32(4), 1001-1009. https://doi.org/10.1016/j.numecd.2021.11.010