Document Type

Journal Article

Publication Title

Nutrition, Metabolism and Cardiovascular Diseases

Volume

32

Issue

4

First Page

1001

Last Page

1009

PubMed ID

35086766

Publisher

Elsevier

School

School of Medical and Health Sciences / Centre for Precision Health

RAS ID

42776

Funders

Application and Evaluation of Active Health Cloud Platform in China, National Key R&D Program of China (2018YFC2000704), China-Australian Collaborative Grant (NSFC 81561128020-NHMRC APP1112767).

Grant Number

81561128020 -NHMRC APP1112767

Grant Link

http://purl.org/au-research/grants/nhmrc/1112767

Comments

Zhang, X., Wang, B., Geng, T., Liu, D., Tian, Q., Meng, X., ... & Wang, B. (2022). Causal associations between COVID-19 and Atrial Fibrillation: A bidirectional Mendelian randomization study. Nutrition, Metabolism and Cardiovascular Diseases, 32(4), 1001-1009. https://doi.org/10.1016/j.numecd.2021.11.010

Abstract

Background and aims: Observational studies showed that coronavirus disease (2019) (COVID-19) attacks universally and its most menacing progression uniquely endangers the elderly with cardiovascular disease (CVD). The causal association between COVID-19 infection or its severity and susceptibility of atrial fibrillation (AF) remains unknown. Methods and results: The bidirectional causal relationship between COVID-19 (including COVID-19, hospitalized COVID-19 compared with not hospitalized COVID-19, hospitalized COVID-19 compared with the general population, and severe COVID-19) and AF are determined by using two-sample Mendelian randomization (MR) analysis. Genetically predicted severe COVID-19 was not significantly associated with the risk of AF [odds ratio (OR), 1.037; 95% confidence interval (CI), 1.005–1.071; P = 0.023, q = 0.115]. In addition, genetically predicted AF was also not causally associated with severe COVID-19 (OR, 0.993; 95% CI, 0.888–1.111; P = 0.905, q = 0.905). There was no evidence to support the association between genetically determined COVID-19 and the risk of AF (OR, 1.111; 95% CI, 0.971–1.272; P = 0.127, q = 0.318), and vice versa (OR, 1.016; 95% CI, 0.976–1.058; P = 0.430, q = 0.851). Besides, no significant association was observed for hospitalized COVID-19 with AF. MR-Egger analysis indicated no evidence of directional pleiotropy. Conclusion: Overall, this MR study provides no clear evidence that COVID-19 is causally associated with the risk of AF.

DOI

10.1016/j.numecd.2021.11.010

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Research Themes

Health

Priority Areas

Multidisciplinary biological approaches to personalised disease diagnosis, prognosis and management

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