Title

Preterm birth and infant diurnal cortisol regulation

Document Type

Journal Article

Publication Title

Archives of Disease in Childhood: Fetal & Neonatal

Publisher

BMJ Publishing Group

School

School of Nursing and Midwifery / Centre for Nursing, Midwifery and Health Services Research

RAS ID

44318

Funders

Theirworld MRC Centre for Reproductive Health British Heart Foundation

Comments

Stoye, D. Q., Boardman, J. P., Osmond, C., Sullivan, G., Lamb, G., Black, G. S., . . . Mörelius, E. (2022). Preterm birth and infant diurnal cortisol regulation. Archives of Disease in Childhood: Fetal & Neonatal. Advance online publication. https://doi.org/10.1136/archdischild-2021- 323296

Abstract

Background Hypothalamic-pituitary-adrenal (HPA) axis adaptation is a potential mechanism linking early life exposures with later adverse health. This study tested the hypothesis that preterm birth is associated with adaptation of diurnal cortisol regulation across infancy. Methods A secondary analysis was conducted of saliva cortisol measured morning, midday and evening, monthly, across infancy, as part of a birth cohort conducted in Linköping, Sweden. Diurnal cortisol regulation of infants born extremely preterm (n=24), very preterm (n=27) and at term (n=130) were compared across infancy through random coefficients regression models. Results Compared with infants born at term, infants born extremely preterm (−17.2%, 95% CI: −30.7 to −1.2), but not very preterm (1.7%, 95% CI: −14.1 to 20.4), had a flattened diurnal slope across infancy. Conclusions Extremely preterm birth is associated with a flattened diurnal slope in infancy. This pattern of cortisol regulation could contribute to adverse metabolic and neurodevelopmental phenotypes observed in this population.

DOI

10.1136/archdischild-2021- 323296

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