Title

Loading of artesunate with MIL100(Fe) nanoparticles and evaluation of anti-cancer activity in a human breast cancer cell line

Document Type

Journal Article

Publication Title

International Journal of Drug Delivery Technology

Volume

12

Issue

1

First Page

401

Last Page

407

Publisher

International Society for Science and Nature

School

School of Engineering

Comments

Haydar, M. A., Gedawy, A., Abide, H. R., Zargar, M., Brook, N., Dass, C., & Sunderland, B. (2022). Loading of Artesunate with MIL100 (Fe) Nanoparticles and Evaluation of Anti-cancer Activity in a Human Breast Cancer Cell Line, 12(1), p. 401-407. https://doi.org/10.25258/ijddt.12.1.72

Abstract

Artesunate (ART), an anti-malarial drug, is nowadays used for the treatment of several types of cancers. It is sparingly soluble in water; therefore, it requires the development of a modified formulation of this drug to enhance its water solubility and stability. MIL100(Fe) nanoparticles, a metal-organic framework, were selected as the drug carrier. Purpose: This study aimed to employ MIL-100 (Fe) as a carrier for ART to investigate the release profile of ART and evaluate in vitro its anti-cancer activity. Methods: ART loading was achieved by mixing ART with MIL100(Fe) in the proportion of (1:1) and (1:2) to form ART-1MIL100(Fe) and ART-2MIL100(Fe), respectively. Only ART-2MIL100(Fe) was coated with 0.5% chitosan (CH) to form CH-ART-2MIL100(Fe). Free ART, ART-2MIL100(Fe), and CH-ART-2MIL100(Fe) were evaluated for anti-cancer activity in a human breast cancer cell line. Results: The ART loading capacity was 65% ± 1.3 and 75% ± 2.2 for ART-MIL100(Fe) and ART-2MIL100(Fe), respectively. The release profiles showed 50% ± 2.3 and 63% ± 1.5 of cumulative ART percent release for ART-2MIL100(Fe) and CH-ART-2MIL100(Fe), respectively. Although free ART demonstrated inhibition of cell viability (81%), ART-2MIL100(Fe) and CH-ART-2MIL100(Fe) showed cell inhibition viability of 56 and 51%, respectively. Conclusion: ART loading within MIL100(Fe) was effective and in vitro breast anti-cancer effect was significant.

DOI

10.25258/ijddt.12.1.72

Access Rights

free_to_read

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