Document Type

Journal Article

Publication Title

Air Medical Journal

Volume

41

Issue

3

First Page

298

Last Page

302

PubMed ID

35595338

Publisher

Elsevier

School

School of Medical and Health Sciences / School of Nursing and Midwifery / Centre for Precision Health

Funders

Department of Health

Comments

Walsh, B. S., Gardiner, F. W., Bloxsome, D., Ford, D., Mills, B. W., & Laws, S. M. (2022). A cohort comparison study on women in threatened preterm labor given nifedipine or nifedipine and salbutamol tocolysis in air medical retrieval. Air Medical Journal, 41(3), p. 298-302. https://doi.org/10.1016/j.amj.2022.02.005

Abstract

Objective: Women with threatened preterm labor in remote Australia often require tocolysis in the prevention of in-flight birth during air medical retrieval. However, debate exists over the tocolytic choice. Methods: A retrospective analysis was undertaken on data containing women who required air medical retrieval for threatened preterm labor within Western Australia between the years 2013 and 2018. Results: A total number of 236 air medical retrievals were deemed suitable for inclusion; 141 received nifedipine, and 95 women received salbutamol + nifedipine. Tocolytic efficaciousness was reported in 151 cases, proportionally more (P < .05) from the women who received salbutamol + nifedipine (n = 68, 71.6%) compared with the women who received nifedipine only (n = 83, 58.9%). Those receiving salbutamol + nifedipine were more likely to suffer maternal tachycardia (n = 87 [91.6%] vs. n = 62 [44.0%]), fetal tachycardia (n = 26 [27.4%] vs. n = 13 [9.2%]), nausea (n = 17 [17.9] vs. n = 5 [3.55%]), and vomiting (n = 12 [12.6%] vs. n = 2 [1.4%]). Three women who received salbutamol + nifedipine had serious side effects including echocardiographic changes, chest pain, and metabolic and lactic acidosis. Conclusion: Salbutamol + nifedipine tocolysis was proven to be more effective than nifedipine only. Although salbutamol + nifedipine had increased temporary side effects, most were nonsevere and managed in-flight.

DOI

10.1016/j.amj.2022.02.005

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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