Journal of Investigative Dermatology
School of Medical and Health Sciences
Graduate Training Centre GRK 1789 Cellular and Molecular Mechanisms in Aging, by the Deutsche Forschungsgemeinschaft (German Research Foundation) – Project-ID 251293561 – SFB 1149 Trauma – Project-C5 RHEACELL GmbH & Co KG Baustein Program from the Medical Faculty, Ulm University (L.SBN.0154) National Institutes of Health (Bethesda, MD) grants NR015649, AR073614, and DK119085
Severe angiopathy is a major driver for diabetes-associated secondary complications. Knowledge on the underlying mechanisms essential for advanced therapies to attenuate these pathologies is limited. Injection of ABCB5+ stromal precursors at the edge of nonhealing diabetic wounds in a murine db/db model, closely mirroring human type 2 diabetes, profoundly accelerates wound closure. Strikingly, enhanced angiogenesis was substantially enforced by the release of the ribonuclease angiogenin from ABCB5+ stromal precursors. This compensates for the profoundly reduced angiogenin expression in nontreated murine chronic diabetic wounds. Silencing of angiogenin in ABCB5+ stromal precursors before injection significantly reduced angiogenesis and delayed wound closure in diabetic db/db mice, implying an unprecedented key role for angiogenin in tissue regeneration in diabetes. These data hold significant promise for further refining stromal precursors–based therapies of nonhealing diabetic foot ulcers and other pathologies with impaired angiogenesis.
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