Document Type

Journal Article

Publication Title

Biomedicines

Volume

10

Issue

2

Publisher

MDPI

School

Centre for Precision Health / School of Medical and Health Sciences

RAS ID

45164

Funders

KWF Kankerbestrijding (grant number 6905) Stichting Coolsingel (grant number 495) Bayer Ophthalmic Research award (BORA) (2021)

Comments

de Bruyn, D. P., Beasley, A. B., Verdijk, R. M., van Poppelen, N. M., Paridaens, D., de Keizer, R. O., ... & Kiliç, E. (2022). Is Tissue Still the Issue? The Promise of Liquid Biopsy in Uveal Melanoma. Biomedicines, 10(2), 506.

https://doi.org/10.3390/biomedicines10020506

Abstract

Uveal melanoma (UM) is the second most frequent type of melanoma. Therapeutic options for UM favor minimally invasive techniques such as irradiation for vision preservation. As a consequence, no tumor material is obtained. Without available tissue, molecular analyses for gene expression, mutation or copy number analysis cannot be performed. Thus, proper patient stratification is impossible and patients' uncertainty about their prognosis rises. Minimally invasive techniques have been studied for prognostication in UM. Blood-based biomarker analysis has become more common in recent years; however, no clinically standardized protocol exists. This review summarizes insights in biomarker analysis, addressing new insights in circulating tumor cells, circulating tumor DNA, extracellular vesicles, proteomics, and metabolomics. Additionally, medical imaging can play a significant role in staging, surveillance, and prognostication of UM and is addressed in this review. We propose that combining multiple minimally invasive modalities using tumor biomarkers should be the way forward and warrant more attention in the coming years.

DOI

10.3390/biomedicines10020506

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Research Themes

Health

Priority Areas

Multidisciplinary biological approaches to personalised disease diagnosis, prognosis and management

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