Document Type

Journal Article

Publication Title





7 July

PubMed ID





School of Medical and Health Sciences / Centre for Exercise and Sports Science Research


Chalchat, E., Gaston, A. F., Charlot, K., Peñailillo, L., Valdés, O., Tardo-Dino, P. E., ... & Siracusa, J. (2022). Appropriateness of indirect markers of muscle damage following lower limbs eccentric-biased exercises: A systematic review with meta-analysis. PloS one, 17(7), e0271233.


Purpose The aim of this review was to (1) characterize the time-course of markers of exercise-induced muscle damage (EIMD) based on the level of maximal voluntary contraction torque loss at 24-48h post-exercise (MVCloss24-48h), (2) identify factors (e.g., exercise and population characteristics) affecting the level of MVCloss24-48h, and (3) evaluate the appropriateness of EIMD markers as indicators of MVCloss24-48h. Methods Magnitude of change of each EIMD markers was normalized using the standardized mean differences method to compare the results from different studies. Time-course of EIMD markers were characterized according to three levels of MVCloss24-48h based on a clustering analysis of the 141 studies included. Association between MVCloss24-48h levels and participant´s characteristics or exercise type/modalities were assessed. Meta-regressions were performed to investigate the associations between MVCloss24-48h and EIMD markers changes at <6h, 24h, 48h, 72h and > 96h after exercise. Results Time-course of EIMD markers recovery differs between levels of MVCloss24-48h. Training status and exercise type/modality were associated with MVCloss24-48h level (p < 0.05). MVCloss24-48h was correlated to changes in myoglobin concentration ( < 6h), jump height (24h) and range of motion (48h) (p < 0.001). Conclusion As the exercise could differently affect markers as function of the EIMD severity (i.e., MVCloss24-48h levels), different markers should be used as function of the timing of measurement. Mb concentration should be used during the first hours after the exercise ( < 6h), whereas jump height (24h) and range of motion (48h) could be used as surrogate for maximal voluntary contraction later. Moreover, training status and exercise type/modality could influence the magnitude of MVCloss24-48h



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Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.