Document Type

Journal Article

Publication Title

Nature

Volume

606

Issue

7912

First Page

113

Last Page

119

PubMed ID

35585233

Publisher

Nature

School

School of Science

RAS ID

44382

Funders

Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science (CE200100012) / National Health and Medical Research Council (grant APP1176553) /

Further funding information available at:

https://doi.org/10.1038/s41586-022-04732-y

Grant Number

ARC Number : CE200100012NHMRC Number : APP1176553

Comments

Kamal, N., Tsardakas Renhuldt, N., Bentzer, J., Gundlach, H., Haberer, G., Juhász, A., ... & Sirijovski, N. (2022). The mosaic oat genome gives insights into a uniquely healthy cereal crop. Nature, 606(7912), 113-119.

https://doi.org/10.1038/s41586-022-04732-y

Abstract

Cultivated oat (Avena sativa L.) is an allohexaploid (AACCDD, 2n = 6x = 42) thought to have been domesticated more than 3,000 years ago while growing as a weed in wheat, emmer and barley fields in Anatolia1,2. Oat has a low carbon footprint, substantial health benefits and the potential to replace animal-based food products. However, the lack of a fully annotated reference genome has hampered efforts to deconvolute its complex evolutionary history and functional gene dynamics. Here we present a high-quality reference genome of A. sativa and close relatives of its diploid (Avena longiglumis, AA, 2n = 14) and tetraploid (Avena insularis, CCDD, 2n = 4x = 28) progenitors. We reveal the mosaic structure of the oat genome, trace large-scale genomic reorganizations in the polyploidization history of oat and illustrate a breeding barrier associated with the genome architecture of oat. We showcase detailed analyses of gene families implicated in human health and nutrition, which adds to the evidence supporting oat safety in gluten-free diets, and we perform mapping-by-sequencing of an agronomic trait related to water-use efficiency. This resource for the Avena genus will help to leverage knowledge from other cereal genomes, improve understanding of basic oat biology and accelerate genomics-assisted breeding and reanalysis of quantitative trait studies.

DOI

10.1038/s41586-022-04732-y

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This work is licensed under a Creative Commons Attribution 4.0 License.

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