Title

Ginger and its active compounds in cancer therapy: From folk uses to nano-therapeutic applications

Document Type

Journal Article

Publication Title

Seminars in Cancer Biology

Volume

69

First Page

140

Last Page

149

PubMed ID

31412298

Publisher

Elsevier

School

Centre for Integrative Metabolomics and Computational Biology / School of Science

RAS ID

31051

Comments

Mahomoodally, M. F., Aumeeruddy, M. Z., Rengasamy, K. R. R., Roshan, S., Hammad, S., Pandohee, J., ... Zengin, G. (2021). Ginger and its active compounds in cancer therapy: From folk uses to nano-therapeutic applications. Seminars in Cancer Biology, 69, 140-149. https://doi.org/10.1016/j.semcancer.2019.08.009

Abstract

Ginger is a spice that is renowned for its characteristic aromatic fragrance and pungent taste, with documented healing properties. Field studies conducted in several Asian and African countries revealed that ginger is used traditionally in the management of cancer. The scientific community has probed into the biological validation of its extracts and isolated compounds including the gingerols, shogaols, zingiberene, and zingerone, through in-vitro and in-vivo studies. Nonetheless, an updated compilation of these data together with a deep mechanistic approach is yet to be provided. Accordingly, this review highlights the mechanisms and therapeutics of ginger and its bioactive compounds focused on a cancer context and these evidence are based on the (i) cytotoxic effect against cancer cell lines, (ii) enzyme inhibitory action, (iii) combination therapy with chemotherapeutic and phenolic compounds, (iv) possible links to the microbiome and (v) the use of nano-formulations of ginger bioactive compounds as a more effective drug delivery strategy in cancer therapy.

DOI

10.1016/j.semcancer.2019.08.009

Research Themes

Health

Priority Areas

Prevention, detection and management of cancer and other chronic diseases

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