Author Identifier

Catherine P. Bondonno

ORCID : 0000-0001-8509-439X

Samantha L. Gardener

ORCID : 0000-0002-1933-5260

Joshua Lewis

ORCID : 0000-0003-1003-8443

Jonathan M. Hodgson

ORCID : 0000-0001-6184-7764

Document Type

Journal Article

Publication Title

Alzheimer's & Dementia: Translational Research & Clinical Interventions (TRCI)




School of Medical and Health Sciences / Centre of Excellence for Alzheimer's Disease Research and Care




Edith Cowan University - Open Access Support Scheme 2021


Bondonno, C. P., Bondonno, N. P., Dalgaard, F., Murray, K., Gardener, S. L., Martins, R. N., ... Hodgson, J. M. (2021). Flavonoid intake and incident dementia in the Danish diet, cancer, and health cohort. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 7(1), article e12175.

Additional Information


Prospective studies investigating flavonoid intake and dementia risk are scarce. The aims of this study were to examine associations between flavonoid intake and the risk of incident dementia and to investigate whether this association differs in the presence of lifestyle risk factors for dementia.


We examined associations in 55,985 participants of the Danish Diet, Cancer, and Health Study followed for 23 years. The Phenol-Explorer database was used to estimate flavonoid intakes. Information on incident dementia and dementia subtypes was obtained using Danish patient and prescription registries. Hazard ratios (HRs) were calculated using restricted cubic splines in multivariable-adjusted Cox proportional hazards models.


For incident dementia, moderate compared to low intakes of flavonols (HR: 0.90 [0.82, 0.99]), flavanol oligo+polymers (HR: 0.87 [0.79, 0.96]), anthocyanins (HR: 0.84 [0.76, 0.93]), flavanones (HR: 0.89 [0.80, 0.99]), and flavones (HR: 0.85 [0.77, 0.95]) were associated with a lower risk. For vascular dementia, moderate intakes of flavonols (HR: 0.69 [0.53, 0.89]) and flavanol oligo + polymers (HR: 0.65 [0.51, 0.83]) were associated with lower risk. Flavonoid intakes were not significantly associated with Alzheimer's disease or unspecified dementia. The inverse association between total flavonoid intake and incident dementia was stronger in “ever” smokers than in “never” smokers and in those without hypercholesterolemia versus those with hypercholesteremia. Furthermore, the inverse association of vascular dementia with a moderate total flavonoid intake was stronger in “ever” smokers and those who were “normal” to “overweight” versus “never” smokers or those who were “obese,” respectively.


A moderate intake of flavonoid-rich foods may help to reduce dementia risk.



Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.