Title

Triglyceride glucose index and carotid atherosclerosis incidence in the Chinese population: A prospective cohort study

Author Identifier

Wei Wang

ORCID : 0000-0002-1430-1360

Document Type

Journal Article

Publication Title

Nutrition, Metabolism & Cardiovascular Diseases

Volume

31

Issue

7

First Page

2042

Last Page

2050

PubMed ID

34045133

Publisher

Elsevier

School

School of Medical and Health Sciences

RAS ID

35934

Funders

National Science Foundation of China

Comments

Wu, Z., Wang, J., Li, Z., Han, Z., Miao, X., Liu, X., ... Tao, L. (2021). Triglyceride glucose index and carotid atherosclerosis incidence in the Chinese population: A prospective cohort study. Nutrition, Metabolism & Cardiovascular Diseases, 31(7), 2042-2050. https://doi.org/10.1016/j.numecd.2021.03.027

Abstract

Background and aims: The association of the triglyceride glucose (TyG) index with carotid atherosclerosis has not been reported in longitudinal studies. The present study aimed to investigate whether the TyG index increases the risk of carotid atherosclerosis incidence. Methods and results: This study included data from the Beijing Health Management Cohort (BHMC; n = 6955) and the Beijing Physical Examination Cohort (BPEC; n = 8473). Participants without a history of carotid atherosclerosis who underwent health examination in 2011 or 2012 were annually followed until 2019. The TyG index was denoted as ln [triglycerides (mmol/L)∗fasting glucose (mmol/L)/2]. During a median follow-up of 5.02 years and 5.36 years, 1441 individuals in the BHMC group and 2181 individuals in the BPEC group developed carotid plaque, respectively. The adjusted hazard ratios (HRs) of the continuous TyG index were 1.253 (95% CI, 1.044 to 1.505) and 1.252 (95% CI, 1.091 to 1.437) for the BHMC and BPEC groups, respectively. Individuals in the highest quartile of the TyG index were associated with an increased risk of carotid plaque compared with those in the lowest quartile (BHMC: HR, 1.366; 95% CI, 1.101 to 1.695, P for trend = 0.010; BPEC: HR, 1.379; 95% CI, 1.196 to 1.591, P for trend = 0.013). Conclusion: These findings suggested that a higher TyG index increases the risk of carotid atherosclerosis incidence in the general population.

DOI

10.1016/j.numecd.2021.03.027

Research Themes

Health

Priority Areas

Multidisciplinary biological approaches to personalised disease diagnosis, prognosis and management

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