Author Identifier

Marc Sim

ORCID : 0000-0001-5166-0605

Jonathan Hodgson

ORCID : 0000-0001-6184-7764

Lauren Blekkenhorst

ORCID : 0000-0003-1561-9052

Nicola Bondonno

ORCID : 0000-0001-5905-444X

Catherine Bondonno

ORCID : 0000-0001-8509-439X

Joshua Lewis

ORCID : 0000-0003-1003-8443

Document Type

Journal Article

Publication Title




First Page


Last Page


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Institute for Nutrition Research / School of Medical and Health Sciences




National Health and Medical Research Council

Further funding information :

Grant Number

NHMRC Numbers : 254627, 303169, 572604, 1159914, 1172987


This is an author's accepted manuscript of:

Gebre, A. K., Sim, M., Rodríguez, A. J., Hodgson, J. M., Blekkenhorst, L. C., Szulc, P., ... Lewis, J. R. (2021). Abdominal aortic calcification is associated with a higher risk of injurious fall-related hospitalizations in older Australian women. Atherosclerosis, 328, 153-159.


Backgrounds and aims: Abdominal aortic calcification (AAC) is associated with weaker grip strength, an established risk factor for fall-related hospitalizations. However, its association with long-term fall-related hospitalisations remains unknown. This study investigated the association between AAC and long-term fall-related hospitalizations in community-dwelling older women. Methods: Fall-related hospitalizations were obtained from linked data over 14.5-years in a prospective cohort of 1053 older women (mean age 75.0 ± 2.6 years). At baseline (1998/99), AAC was assessed from lateral spine images obtained using dual-energy X-ray absorptiometry, and scored using a semi-quantitative method (AAC24, range 0–24). The presence of any AAC was defined by AAC24 ≥ 1. Results: Over 14.5-years, 413 (39.2%) women experienced a fall-related hospitalization. In the multivariable-adjusted model, each unit increase in baseline AAC24 was associated with a 3% increase in relative hazards for a fall-related hospitalization (HR 1.03 95%CI, 1.01 to 1.07). Compared to women with no AAC, women with any AAC had a 40% (HR 1.40 95%CI, 1.11 to 1.76) and 39% (HR 1.39 95%CI, 1.10 to 1.76) greater risk for fall-related hospitalizations in the minimal and multivariable-adjusted models, respectively. This relationship was not attenuated by including measures of muscle function such as grip strength and timed-up-and-go. Conclusions: The presence of AAC is associated with long-term fall-related hospitalizations risk, independent of muscle function, in community-dwelling older women. Concurrent assessment of AAC may be a simple and cost-effective way to identify older women at higher risk of falling as part of routine osteoporosis screening.



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Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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