Document Type

Journal Article

Publication Title

Integrative Cancer Therapies




School of Medical and Health Sciences / Graduate Research / Exercise Medicine Research Institute / Centre for Exercise and Sports Science Research / Centre for Precision Health




Edith Cowan University - Open Access Support Scheme 2021

Cancer Council WA

Paul Katris Honours and Masters Scholarship

National Health and Medical Research Council

Grant Number

NHMRC Number : 1190643


Crosby, B. J., Lopez, P., Galvão, D. A., Newton, R. U., Taaffe, D. R., Meniawy, T. M., . . . Singh, F. (2021). Associations of physical activity and exercise with health-related outcomes in patients with melanoma during and after treatment: A systematic review. Integrative Cancer Therapies, 20, 1-11.



Although exercise medicine is recommended to counter treatment-related side-effects and improve health-related outcomes of patients affected by different cancers, no specific recommendations exist for patients with melanoma. As a result, we systematically examined the current evidence regarding the effects of physical activity and exercise on objectively-measured and patient-reported outcomes among patients with melanoma.


Searches were conducted in PubMed, CINAHL, EMBASE, SPORTDiscus, and Web of Science databases. This review included published data involving physical activity or exercise and objectively-measured or patient-reported outcomes of patients with cutaneous melanoma. The quality of included studies was assessed using the McMaster University Critical Appraisal Tool for Quantitative Studies.


Six studies including 882 patients with melanoma were included. Studies presented heterogeneity of design with 2 cross-sectional surveys, 2 retrospective analyses, and 2 non-randomized intervention trials. No statistically significant change in quality of life, fatigue, physical function, cardiorespiratory fitness, body composition, psychological distress, cognitive function, or treatment-related side-effects were attributable to physical activity or exercise. Importantly, physical activity or exercise during melanoma treatment or into survivorship did not adversely impact patients/survivors.


In summary, physical activity or exercise did not adversely impact quality of life, objectively-measured or patient-reported outcomes in patients with melanoma. In addition, there is a paucity of quality studies examining the effects of physical activity or exercise on patients with melanoma throughout the cancer care continuum.



Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License