Higher habitual dietary flavonoid intake associates with lower central blood pressure and arterial stiffness in healthy older adults

Author Identifier

Catherine Bondonno

ORCID : 0000-0001-8509-439X

Jonathan Hodgson

ORCID : 0000-0001-6184-7764

Nicola Bondonno

ORCID : 0000-0001-5905-444X

Document Type

Journal Article

Publication Title

British Journal of Nutrition






Cambridge University Press


School of Medical and Health Sciences / Institute for Nutrition Research




Australian Research Council


Soho Flordis

International Research and Blackmores

Doug Mitchell

Roderic O'Connor

Australian Government

National Health and Medical Research Council

Heart Foundation

Future Leader Fellowship

Grant Number

ARC Number : DP1093825 NHMRC Numbers : APP1159914, APP1116937


Parmenter, B. H., Croft, K. D., Cribb, L., Cooke, M. B., Bondonno, C. P., Lea, A., . . . Bondonno, N. P. (2022). Higher habitual dietary flavonoid intake associates with lower central blood pressure and arterial stiffness in healthy older adults. British Journal of Nutrition, 128(2), 279-289.



Flavonoids have shown anti-hypertensive and anti-atherosclerotic properties: the impact of habitual flavonoid intake on vascular function, central hemodynamics and arterial stiffness may be important. We investigated the relationship between habitual flavonoid consumption and measures of central blood pressure and arterial stiffness. We performed cross-sectional analysis of 381 non-smoking healthy older adults (mean ± SD age, 66.0 ± 4.1 years; BMI, 26.4 ± 4.41 kg/m2; 41% male) recruited as part of the Australian Research Council Longevity Intervention (ARCLI) study. Flavonoid intake [i.e., flavonols, flavones, flavanones, anthocyanins, isoflavones, flavan-3-ol monomers, proanthocyanidins, theaflavins/thearubigins and total consumption] was estimated from food-frequency questionnaires using the US Department of Agriculture food composition databases. Measures of central hemodynamics and arterial stiffness included systolic blood pressure (cSBP), diastolic blood pressure (cDBP), mean arterial pressure (cMAP), and augmentation index (cAIx). After adjusting for demographic and lifestyle confounders, each standard deviation (SD)/day higher intake of anthocyanins (SD = 44.3 mg/day) was associated with significantly lower cDBP (-1.56 mmHg, 95 % CI: -2.65, -0.48) and cMAP (-1.62 mmHg, 95 % CI: -2.82, -0.41). Similarly, each SD/day higher intake of flavanones (SD = 19.5 mg/day) was associated with 1 % lower cAIx (-0.93 %, 95 % CI: -1.77, -0.09). These associations remained signi cant after additional adjustment for 1) a dietary quality score and 2) other major nutrients that may affect blood pressure or arterial stiffness (i.e., sodium, potassium, calcium, magnesium, omega-3, total protein and fibre). This study suggests a possible benefit of dietary anthocyanin and flavanone intake on central hemodynamics and arterial stiffness; these findings require corroboration in further research.



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