Authors
Enoch O. Anto, Edith Cowan UniversityFollow
David A. Coall, Edith Cowan UniversityFollow
Otchere Addai-Mensah
Yaw Amo Wiafe
William K. B. A. Owiredu
Christian Obirikorang
Max E. Annani-Akollor
Eric Adua, Edith Cowan UniversityFollow
Augustine Tawiah
Emmanuel Acheampong, Edith Cowan UniversityFollow
Evans Adu Asamoah
Xueqing Wang, Edith Cowan UniversityFollow
Stephen Opoku
Derick Kyei Boakye
Haifeng Hou, Edith Cowan UniversityFollow
Youxin Wang, Edith Cowan UniversityFollow
Wei Wang, Edith Cowan UniversityFollow
Document Type
Journal Article
Publication Title
EPMA Journal
Volume
12
Publisher
Springer
School
School of Medical and Health Sciences / Centre for Precision Health
RAS ID
39767
Funders
The Australia-China International Collaborative Grant
Edith Cowan University
National Health and Medical Research Council
Grant Number
NHMRC Number : APP1112767
Abstract
Pregnant women, particularly in developing countries are facing a huge burden of preeclampsia (PE) leading to high morbidity and mortality rates. This is due to delayed diagnosis and unrecognised early targeted preventive measures. Adapting innovative solutions via shifting from delayed to early diagnosis of PE in the context of predictive diagnosis, targeted prevention and personalisation of medical care (PPPM/3 PM) is essential. The subjective assessment of suboptimal health status (SHS) and objective biomarkers of oxidative stress (OS) and angiogenic growth mediators (AGMs) could be used as new PPPM approach for PE; however, these factors have only been studied in isolation with no data on their combine assessment. This study profiled early gestational biomarkers of OS and AGMs as 3 PM approach to identify SHS pregnant mothers likely to develop PE specifically, early-onset PE (EO-PE) and late-onset PE (LO-PE).
DOI
10.1007/s13167-021-00258-x
Comments
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s13167-021-00258-x
Anto, E. O., Coall, D. A., Addai-Mensah, O., Wiafe, Y. A., Owiredu, W. K. B. A., Obirikorang, C., . . . Wang, W. (2021). Early gestational profiling of oxidative stress and angiogenic growth mediators as predictive, preventive and personalised (3P) medical approach to identify suboptimal health pregnant mothers likely to develop preeclampsia. EPMA Journal, 12, p. 517-534.
https://doi.org/10.1007/s13167-021-00258-x