Developmental origins of health and disease (DOHaD): The importance of life-course and transgenerational approaches
Paediatric Respiratory Reviews
School of Medical and Health Sciences
Telethon Perth Children's Hospital Research Fund Joondalup Health Campus Paul Ramsay Foundation Commonwealth Government of Australia Channel 7 Telethon Trust Telethon Kid's Institute
With well-established evidence that early life conditions have a profound influence on lifespan and health-span, new interventional birth cohorts are examining ways to optimise health potential of individuals and communities. These are aimed at going beyond preventing disease, to the conditions that facilitate flourishing from an early age. Covering diverse domains, local community projects, such as The ORIGINS Project, are taking a broader approach to the protective and buffering factors that enhance resilience and reduce allostatic load, such as building nature relatedness, interpersonal relationships, mindfulness, and positive emotions. Such cohorts aim to address how ‘upstream’ approaches will have flow on effects to the ‘historical’ risk targets (such as poor nutrition, physical inactivity, and stress) by influencing these core behaviours through better relationships with self, community, and the environment. In addition to scientific pursuit, interventional cohorts can contribute to solutions in every community – nourishing individuals and communities towards positive change.
Hagemann, E., Silva, D. T., Davis, J. A., Gibson, L. Y., & Prescott, S. L. (2021). Developmental origins of health and disease (DOHaD): The importance of life-course and transgenerational approaches. Paediatric Respiratory Reviews, 40, (3-9). https://doi.org/10.1016/j.prrv.2021.05.005