Reduced cardiovascular capacity and resting metabolic rate in men with prostate cancer undergoing androgen deprivation: A comprehensive cross-sectional investigation

Authors

Bradley Wall, Edith Cowan University
Daniel A. Galvao, Edith Cowan UniversityFollow
Naeem Fatehee, Edith Cowan University
Dennis Taaffe, Edith Cowan UniversityFollow
Nigel Spry, Edith Cowan UniversityFollow
David Joseph, Edith Cowan UniversityFollow
Robert Newton, Edith Cowan UniversityFollow

Author Identifier

Daniel A Galvao

https://orcid.org/0000-0002-8209-2281

Dennis Taaffe

https://orcid.org/0000-0001-6381-1597

Nigel Spry

https://orcid.org/0000-0001-8659-5065

Robert U Newton

https://orcid.org/0000-0003-0302-6129

Document Type

Journal Article

Publisher

Hindawi Publishing Corporation

School

Exercise Medicine Research Institute

RAS ID

21246

Funders

National Health and Medical Research Council

Grant Number

NHMRC Number : 534409

Grant Link

http://purl.org/au-research/grants/nhmrc/534409

Comments

Wall, Bradley A. (2015). "Reduced Cardiovascular Capacity and Resting Metabolic Rate in Men with Prostate Cancer Undergoing Androgen Deprivation: A Comprehensive Cross-Sectional Investigation". Advances in urology (1687-6369), 65 (5), p. 1. Available here

Abstract

Objectives. To investigate if androgen deprivation therapy exposure is associated with additional risk factors for cardiovascular disease and metabolic treatment-related toxicities. Methods. One hundred and seven men (42-89 years) with prostate cancer undergoing androgen deprivation therapy completed a maximal graded objective exercise test to determine maximal oxygen uptake, assessments for resting metabolic rate, body composition, blood pressure and arterial stiffness, and blood biomarker analysis. A cross-sectional analysis was undertaken to investigate the potential impact of therapy exposure with participants stratified into two groups according to duration of androgen deprivation therapy (≥3 months). Results. Maximal oxygen uptake (26.1 ± 6.0 mL/kg/min versus 23.2 ± 5.8 mL/kg/min, p = 0.020) and resting metabolic rate (1795 ± 256 kcal/d versus 1647 ± 236 kcal/d, p = 0.005) were significantly higher in those with shorter exposure to androgen deprivation. There were no differences between groups for peripheral and central blood pressure, arterial stiffness, or metabolic profile. Conclusion. Three months or longer exposure to androgen deprivation therapy was associated with reduced cardiorespiratory capacity and resting metabolic rate, but not in a range of blood biomarkers. These findings suggest that prolonged exposure to androgen deprivation therapy is associated with negative alterations in cardiovascular outcomes. Trial registry is: ACTRN12609000200280. © 2015 Bradley A. Wall et al.

DOI

10.1155/2015/976235

Creative Commons License

This work is licensed under a Creative Commons Attribution 3.0 License.