Multidisciplinary Digital Publishing Institute
School of Medical Sciences
National Natural Science Foundation of China
(81561128020, 81370083, 81273170)
National “12th Five-Year” Plan for Science and Technology Support, China (2012BAI37B03)
NHMRC grant #APP1112767
Edith Cowan University-Strategic Research Fund (SRF
EU-fp-7 Pain-Omics (602736)
Beijing Higher Education Young Elite Teacher Project (YETP1671)
Beijing Nova Program (Z141107001814058)
Recovery Medical Science Foundation
NHMRC Number : 1112767
Genome-wide association studies (GWAS) found that IGF2BP2 rs4402960 and rs1470579 polymorphisms were associated with type 2 diabetes mellitus (T2DM) risk. Many studies have replicated this association, but yielded inconsistent results.
Materials and Methods:
A case-control study consisting of 461 T2DM patients and 434 health controls was conducted to detect the genetic susceptibility of IGF2BP2 in a northern Han Chinese population. A meta-analysis was to evaluate the association more precisely in Asians.
In the case-control study, the carriers of TT genotype at rs4402960 had a higher T2DM risk than the G carriers (TG + GG) (adjusted odd ratio (AOR) = 1.962, 95% confidence interval (95% CI) = 1.065-3.612, p = 0.031]; CC carriers at rs1470579 were more susceptible to T2DM than A carriers (CA + AA) (AOR = 2.014, 95% CI = 1.114-3.642, p = 0.021). The meta-analysis containing 36 studies demonstrated that the two polymorphisms were associated with T2DM under the allele comparison, genetic models of dominant and recessive in Asians (p < 0.05). The rs4402960 polymorphisms were significantly associated with the T2DM risk after stratification by diagnostic criterion, size of sample and average age and BMI of cases, while there’re no consistent results for rs1470579.
Our data suggests that IGF2BP2 polymorphisms are associated with T2DM in Asian populations.
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