Abstract
More than half of all known proteins, and almost all membrane and extra-cellular proteins have oligosaccharide structures or glycans attached to them. Defects in glycosylation pathways are directly involved in at least 30 severe human diseases. A multiple center cross-sectional study (China, Croatia, and Scotland) was carried out to investigate the possible association between hypertension and IgG glycosylation. A hydrophilic interaction chromatography of fluorescently labeled glycans was used to analyze N-glycans attached to IgG in plasma samples from a total of 4757 individuals of Chinese Han, Croatian, and Scottish ethnicity. Five glycans (IgG with digalactosylated glycans) significantly differed in participants with prehypertension or hypertension compared to those with normal blood pressure, while additional 17 glycan traits were only significantly differed in participants with hypertension compared to those of normal blood pressure. These glycans were also significant correlated with systolic blood pressure (SBP) or diastolic blood pressure (DBP). The present study demonstrated for the 1st time an association between hypertension and IgG glycome composition. These findings suggest that the individual variation in N-glycosylation of IgG contributes to pathogenesis of hypertension, presumably via its effect on pro-and/or anti-inflammatory pathways.
Keywords
human diseases, proteins, association between hypertension and IgG glycosylation
Document Type
Journal Article
Date of Publication
2016
Publisher
Lippincott Williams and Wilkins
School
School of Medical Sciences
RAS ID
21463
Funders
National Natural Science Foundation of China (81370083, 81273170, 81573215, 81373099)
National “12th Five-Year” Plan for Science and Technology Support, China (2012BAI37B03)
Joint Project of the Australian National Health and Medical Research Council and the National Natural Science Foundation of China (NHMRC-APP1112767-NSFC 81561128020)
Connecting Australian-European Science and Innovation Excellence (CAESIE-Priming Grant 1747853),
Australian National Health and Medical Research Council (NHMRC-APP1046711)
Edith Cowan University Industry Collaboration Scheme 2013 (G1001368)
EU-fp-7 Pain-Omics (602736)
Importation and Development of High-Calibre Talents Project of Beijing Municipal Institutions (CIT&TCD201404185)
Beijing Higher Education Young Elite Teacher Project (YETP1671)
Beijing Nova Program (Z141107001814058)
Russian Science Foundation (14-14-00313)
Medical Research Council UK and the Croatian Science Foundation (8875)
Grant Number
NHMRC Number : 1112767
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Comments
Wang, Y., Klaric, L., Yu, X., Thaqi, K., Dong, J., Novokmet, M., . . . Wang, W. (2016). The association between glycosylation of immunoglobulin G and hypertension: A multiple ethnic cross-sectional study. Medicine, 95(17), e3379.
https://doi.org/10.1097/md.0000000000003379