Document Type

Journal Article


BioMed Central Ltd

Place of Publication

United Kingdom


School of Medical and Health Sciences




Kupaev, V., Borison, O., Marutina, E., Yan, Y., & Wang, W. (2016). Integration of suboptimal health status and endothelial dysfunction as a new aspect for risk evaluation of cardiovascular disease. EPMA Journal, 7(1). Available here.


Background: Suboptimal health status (SHS) is recognized as a subclinical, reversible stage of chronic disease. Association has been confirmed between SHS and cardiovascular risk factors, indicating that SHS may contribute to the development of cardiovascular disease. This study explored integrated risk assessment of cardiovascular disease by combining SHS questionnaire-25 (SHSQ-25) and indicators of endothelial dysfunction. Methods: A community-based cross-sectional study was conducted in a sample of 459 residents of Samara, Russia, who had no history of clinical diagnosed disease and did not receive any treatment in the last 2 weeks. The SHS score was derived from the data collected in the SHSQ-25. Blood pressure, body mass index, and glucose and lipid levels (total cholesterol, low density lipoprotein, cholesterol and triglycerides) were measured by physical examination and laboratory performance. The relationship between SHS and endothelial dysfunction was examined using Pearson's correlation linear regression analysis. Cluster analysis was performed to identify systemic patterns arising from exposure to a variety of risk factors. Results: Significant correlations were observed between index of endothelial function and the overall performance of SHS (r=-0.31, p



Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.