β-Amyloid, APOE and BDNF genotype, and depressive and anxiety symptoms in cognitively normal older women and men
Sophie E. Holmes, Yale University
Irina Esterlis, Yale Univesity
Carolyn M. Mazure, Yale University
Yenying Lim, University of Melbourne
David J. Ames, University of Melbourne
Stephanie R. Rainey-Smith, Edith Cowan UniversityFollow
Ralph N. Martins, Edith Cowan UniversityFollow
Olivier Salvado, Commonwealth Scientific and Industrial Research Organization, Australian E-Health Research Centre
Vincent Doré, Austin Health, Department of Molecular Imaging and Therapy, Heidelberg, Australia
Victor L. Villemagne, Austin Health, Department of Molecular Imaging and Therapy, Heidelberg, Australia
Christopher C. Rowe, Austin Health, Department of Molecular Imaging and Therapy, Heidelberg, Australia
Simon M. LawsFollow
C. L. Masters, University of Melbourne
Paul T. Maruff, University of Melbourne
Robert H. Pietrzak, VA Medical Center, United States
Australian Imaging, Biomarkers, Lifestyle Research Group
The American Journal of Geriatric Psychiatry
Place of Publication
School of Medical and Health Sciences
National Health and Medical Research Council
NHMRC Number : 1009292
To examine how β-amyloid (Aβ), APOE and BDNF genotypes, and cortisol relate to depressive and anxiety symptoms in cognitively normal older women and men.
Cross-sectional data were analyzed from 423 older adults from the Australian Imaging Biomarkers and Lifestyle study. Analyses of covariance evaluated associations between Aβ, APOE and BDNF genotype, and cortisol in relation to severity of depressive and anxiety symptoms.
Among Aβ+ older adults, APOE ε4 carriage was associated with greater severity of anxiety symptoms (d = 0.55); and in the full sample, APOE ε4 carriage was linked to greater severity of depressive (d = 0.26) and anxiety (d = 0.21) symptoms. Among Aβ+ women, ε4 carriers reported greater anxiety symptoms than non-ε4 carriers (d = 0.83), and female BDNF rs6265 Val66 Met allele carriers reported greater depressive symptoms (d = 0.29).
Sex moderated the relationship between Aβ, APOE genotype, and BDNF genotype in predicting severity of anxiety and depressive symptoms in cognitively normal older adults.