Neuromuscular changes and damage after isoload versus isokinetic eccentric exercise

Document Type

Journal Article


Lippincott Williams and Wilkins

Place of Publication

United States


School of Medical and Health Sciences / Centre for Exercise and Sports Science Research




Doguet, V., Nosaka, K., Plautard, M., Gross, R., Guilhem, G., Guével, A., & Jubeau, M. (2016). Neuromuscular Changes and Damage after Isoload versus Isokinetic Eccentric Exercise. Medicine & Science in Sports & Exercise, 48(12), 2526-2535. Available here.


Purpose This study compared the effects of isoload (IL) and isokinetic (IK) knee extensor eccentric exercises on changes in muscle damage and neuromuscular parameters to test the hypothesis that the changes would be different after IL and IK exercises. Methods Twenty-two young men were paired based on their strength and placed in the IL (N = 11) or the IK (N = 11) group. The IL group performed 15 sets of 10 eccentric contractions with a 150% of predetermined one-repetition maximum load. The IK group performed 15 sets of several maximal eccentric contractions matched set by set for the total amount of work and mean angular velocity with the IL group. Muscle damage markers (voluntary isometric peak torque, muscle soreness, and creatine kinase activity) and neuromuscular variables (e.g., voluntary activation, H-reflex, M-wave, and evoked torque) were measured before, immediately after, and 24, 48, 72, and 96 h postexercise. Results Voluntary isometric peak torque decreased to the same extent (P = 0.94) in both groups immediately after (IL = -40.6% ± 13.8% vs IK = -42.4% ± 10.2%) to 96 h after the exercise (IL = -21.8% ± 28.5% vs IK = -26.7% ± 23.5%). Neither peak muscle soreness (IL = 48.1 ± 28.2 mm vs IK = 54.7 ± 28.9 mm, P = 0.57) nor creatine kinase activity (IL = 12,811 ± 22,654 U·L-1 vs IK = 15,304 ± 24,739 U·L-1, P = 0.59) significantly differed between groups. H-reflex (IL = -23% vs IK = -35%) and M-wave (IL = -10% vs IK = -17%) significantly decreased immediately postexercise similarly between groups. Conclusion The changes in muscle damage and neuromuscular function after the exercise are similar between IL and IK, suggesting that resistance modality has little effects on acute muscle responses. © 2016 by the American College of Sports Medicine.