Muscle mass as a target to reduce fatigue in patients with advanced cancer
Place of Publication
Exercise Medicine Research Institute
Background: Cancer-related fatigue (CRF) reduces quality of life and the activity level of patients with cancer. Cancer related fatigue can be reduced by exercise interventions that may concurrently increase muscle mass. We hypothesized that low muscle mass is directly related to higher CRF. Methods: A total of 233 patients with advanced cancer starting palliative chemotherapy for lung, colorectal, breast, or prostate cancer were studied. The skeletal muscle index (SMI) was calculated as the patient's muscle mass on level L3 or T4 of a computed tomography scan, adjusted for height. Fatigue was assessed with the Functional Assessment of Chronic Illness Therapy-fatigue questionnaire (cut-off for fatigue
Neefjes, E. C., Hurk, R. M., Blauwhoff‐Buskermolen, S., Vorst, M. J., Becker‐Commissaris, A., Schueren, M. A., ... & Verheul, H. M. (2017). Muscle mass as a target to reduce fatigue in patients with advanced cancer. Journal of cachexia, sarcopenia and muscle, 8(4), 623-629. Available here.