School of Medical and Health Sciences / Centre for Excellence in Alzheimer's Disease Research and Care
Edith Cowan University
McCusker Alzheimer's Research Foundation
National Health and Medical Research Council
New discoveries in medicine are required to understand the importance of appetite regulation that is associated with the overconsumption of foodin Type 2 and Type 3 diabetes. Food restriction in diabetes is essential to maintain the hepatic metabolism of dietary fat with relevance to defective post-prandial lipid metabolism and to the global non alcoholic fatty liver disease (NAFLD) epidemic [1,2]. Premature brain aging has become important with the development of Type 3 diabetesand Alzheimer’s disease  that is associated with repression of the anti-aging gene Sirtuin 1 (Sirt 1) relevant topost-prandial lipid metabolism, amyloid beta metabolism (peptide involved in amyloid beta plaques)and circadian rhythm abnormalities in the brain biological clock associated with the development of NAFLD.Nutritional interventions such as very low carbohydrate diets have become important to diabetes (Figure 1) to reverse defective post-prandial lipid and amyloid beta metabolism without atherogenic lipoprotein formation [4,5] with the prevention of accelerated atherosclerosis in various communities [...].
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