Association between IgG N-glycans and nonalcoholic fatty liver disease in Han Chinese

Document Type

Letter to the Editor


Elsevier Ltd


School of Medical and Health Sciences


ZHAO, Z. Y., LIU, D., CAO, W. J., SUN, M., SONG, M. S., WANG, W., & WANG, Y. X. (2018). Association between IgG N-glycans and nonalcoholic fatty liver disease in han chinese. Biomedical and Environmental Sciences, 31(6), 454-458. Available here


Nonalcoholic fatty liver disease (NAFLD) is a major public health issue worldwide. Immunoglobulin G (IgG) N-glycans are associated with risk factors for NAFLD, such as obesity and diabetes. A cross-sectional study involving 500 Han Chinese adults recruited from a community in Beijing was carried out to explore the association between IgG N-glycans and NAFLD. IgG N-glycosylation was significantly associated with NAFLD, with the disease showing a negative correlation with galactosylation (GP14, GP14n, and G2n), positive correlation with fuco sylation (FBG2n/G2n), and positive correlation with bisecting N-acetylglucosamine (GlcNAc) [FBG2n/FG2n and FBG2n/(FG2n+FBG2n)], after controlling age, gender, and prevalence of obesity, type 2 diabetes mellitus, hypertension, and hyperlipidemia. In other words, the present study showed a possible association between NAFLD and the loss of galactose and elevations of fucose and bisecting GlcNAc. Aberrant IgG glycosylation might therefore be a potential biomarker for the primary or secondary prevention of NAFLD.



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