Title

Single gene inactivation with implications to diabetes and multiple organ dysfunction syndrome

Document Type

Journal Article

Publisher

iMedPub

Place of Publication

United States

School

School of Medical and Health Sciences

RAS ID

26268

Comments

Originally published as: Martins, I. J. (2017). Single Gene inactivation with implications to diabetes and multiple organ dysfunction syndrome. Journal of Clinical Epigenetics, 3(3), 24. Original article available here.

Abstract

Nutritional and environmental epigenetics are involved with the repression of anti-aging genes that are linked to the chronic disease epidemic. Unhealthy diets inactivate the calorie sensitive gene Sirtuin 1 (Sirt 1) involved in epigenetic processes that promote immune system alterations, mitochondrial apoptosis, Non-alcoholic Fatty Liver Disease (NAFLD), diabetes and Nitric Oxide (NO) modification with relevance to core body temperature involved with appetite regulation, glucose homeostasis and hepatic xenobiotic metabolism. The interplay between NO and epigenetics has attracted interest with relevance to autoimmune disease and mitophagy that has become of critical concern to diabetes and the development of MODS. Future research involved with nutritional research and the maintenance of Sirt 1 transcriptional control is critical to the prevention of MODS that is linked to the immune system and insulin resistance. In the developing world bacterial lipopolysaccharides a critical repressor of Sirt 1 is now involved with NAFLD and various organ diseases relevant to tissue accumulation of xenobiotics from various environments with relevance to MODS and the global chronic disease epidemic.

DOI

10.21767/2472-1158.100058

Access Rights

Free_to_read

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