Document Type

Journal Article

Publication Title

Sci Rep

ISSN

2045-2322

Volume

8

Issue

1

First Page

14615

Last Page

14615

PubMed ID

30279429

Publisher

Nature

School

School of Medical and Health Sciences

Comments

Originally published as: Reyes, A., Salomonczyk, D., Teo, W. P., Medina, L. D., Bartlett, D., Pirogovsky-Turk, E., ... & Gilbert, P. E. (2018). Computerised dynamic posturography in premanifest and manifest individuals with Huntington’s Disease. Scientific reports, 8(1), 14615. Original article available here

Abstract

Evidence from small-scale studies indicates that impairments in postural stability are an early and disabling feature of Huntington's disease (HD) and may be a useful clinical endpoint for disease modifying trials. Larger studies are needed to confirm these preliminary findings and the suitability of postural stability outcomes as clinical endpoints. Static and dynamic postural stability were evaluated in 54 premanifest HD, 36 manifest HD and 45 healthy individuals using the Sensory Organization Test (SOT) and Limits of Stability (LOS) test. Manifest HD displayed significantly lower scores on all SOT conditions and on the SOT composite score and had more falls than healthy and premanifest HD (p < 0.05). Premanifest and manifest HD demonstrated significantly lower endpoint excursion (p < 0.001), maximum excursion (p ≤ 0.001), and directional control (p ≤ 0.004) values than healthy individuals on the LOS test. Deficits in LOS were found to manifest on the left side of premanifest HD. Significant but low associations were observed between UHDRS-TMS, disease burden score, diagnostic confidence level, SOT conditions and SOT composite score. We confirm here that individuals with premanifest and manifest HD display significant impairments in static and dynamic postural stability. Dynamic posturography assessments should be considered as clinical endpoints for future disease modifying trials.

DOI

10.1038/s41598-018-32924-y

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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