Document Type

Journal Article

Publication Title

Int J Stroke

ISSN

1747-4949

Volume

13

Issue

8

First Page

863

Last Page

880

PubMed ID

30270762

Publisher

Sage Publications Ltd.

Place of Publication

United Kingdom

School

School of Medical and Health Sciences

RAS ID

27660

Grant Number

NHMRC Number: 1044973

Grant Link

http://purl.org/au-research/grants/nhmrc/1044973

Comments

Originally published as: Godecke, E., Rai, T., Cadilhac, D. A., Armstrong, E., Middleton, S., Ciccone, N., ... & Hankey, G. J. (2018). Statistical analysis plan (SAP) for the Very Early Rehabilitation in Speech (VERSE) after stroke trial: an international 3-arm clinical trial to determine the effectiveness of early, intensive, prescribed, direct aphasia therapy. International Journal of Stroke, 13(8), 863-880. Original article available here.

Abstract

Background Limited evidence exists to support very early intensive aphasia rehabilitation after stroke. VERSE is a PROBE trial designed to determine whether two types of intensive aphasia therapy, beginning within 14 days of acute stroke, provide greater therapeutic and cost-effectiveness than usual care. Objective To publish the detailed statistical analysis plan for the VERSE trial prior to unblinding. This statistical analysis plan was based on the published and registered VERSE trial protocol and was developed by the blinded steering committee and management team, led by the trial statistician. This plan was developed using outcome measures and trial data collection forms. Results The VERSE statistical analysis plan is consistent with reporting standards for clinical trials and provides for clear and open reporting. Conclusions Publication of a statistical analysis plan serves to reduce potential trial reporting bias and outlines transparent pre-specified analyses. Australian New Zealand Clinical Trials Registry (ANZCTR) Registration number: ACTRN12613000776707; Universal Trial Number (UTN) is U1111-1145-4130.

DOI

10.1177/1747493018790055

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