Title

Sarcopenia definitions and their associations with mortality in older Australian women

Document Type

Journal Article

Publication Title

Journal of the American Medical Directors Association

ISSN

1538-9375

Volume

20

Issue

1

First Page

76

Last Page

82

PubMed ID

30527277

Publisher

Elsevier B.V.

School

School of Medical and Health Sciences

RAS ID

27563

Grant Number

NHMRC Number : 572604, NHMRC Number : 254627, NHMRC Number : 303169

Grant Link

http://purl.org/au-research/grants/nhmrc/572604

http://purl.org/au-research/grants/nhmrc/254627

http://purl.org/au-research/grants/nhmrc/303169

Comments

Originally published as:

Sim, M., Prince, R. L., Scott, D., Daly, R. M., Duque, G., Inderjeeth, C. A., ... & Lewis, J. R. (2019). Sarcopenia definitions and their associations with mortality in older Australian women. Journal of the American Medical Directors Association, 20(1), 76-82.

Original article available here.

Abstract

OBJECTIVES: To investigate the relationship of 4 sarcopenia definitions with long-term all-cause mortality risk in older Australian women.

DESIGN: Data from the Perth Longitudinal Study in Aging Women from 2003 to 2013 was examined in this prospective cohort study. The 4 sarcopenia definitions were the United States Foundation for the National Institutes of Health (FNIH), the European Working Group on Sarcopenia in Older People (EWGSOP), and adapted FNIH (AUS-POP

SETTING AND PARTICIPANTS: In total, 903 community-dwelling older Australian women (baseline mean age 79.9 ± 2.6 years) with concurrent measures of muscle strength (grip strength), physical function (timed-up-and-go; TUG) and appendicular lean mass (ALM) were included.

MEASURES: Cox-proportional hazards modeling was used to examine the relationship between sarcopenia definitions and mortality over 5 and 9.5 years.

RESULTS: Baseline prevalence of sarcopenia by the 4 definitions differed substantially [FNIH (9.4%), EWGSOP (24.1%), AUS-POP

CONCLUSIONS/RELEVANCE: Unlike FNIH, the EWGSOP sarcopenia definition incorporating weak muscle strength and/or poor physical function was related to prognosis, as was the regionally adapted version of EWGSOP. Although sarcopenia definitions were not developed based on prognosis, this is an important consideration for globally standardizing the sarcopenia framework.

DOI

10.1016/j.jamda.2018.10.016

Access Rights

Free_to_read

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