Title

A case-control genome wide association study of substance use disorder (SUD) identifies novel variants on chromosome 7p14.1 in patients from the United Arab Emirates (UAE)

Document Type

Journal Article

Publication Title

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

ISSN

1552-485X

Volume

180

Issue

1

First Page

68

Last Page

79

PubMed ID

30556296

Publisher

Blackwell Publishing Inc.

School

School of Medical Sciences

Comments

Originally published as: Alblooshi, H., Al Safar, H., Fisher, H. F., Cordell, H. J., El Kashef, A., Al Ghaferi, H., . . . Tay, G. K. (2019). A case–control genome wide association study of substance use disorder (SUD) identifies novel variants on chromosome 7p14.1 in patients from the United Arab Emirates (UAE). American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 180(1), 68-79. Original Article available here

Abstract

Genome wide association studies (GWASs) have provided insights into the molecular basis of the disorder in different population. This study presents the first GWAS of substance use disorder (SUD) in patients from the United Arab Emirates (UAE). The aim was to identify genetic association(s) that may provide insights into the molecular basis of the disorder. The GWAS discovery cohort consisted of 512 (250 cases and 262 controls) male participants from the UAE. Controls with no prior history of SUD were available from the Emirates family registry. The replication cohort consisted of 520 (415 cases and 105 controls) Australian male Caucasian participants. The GWAS discovery samples were genotyped for 4.6 million single nucleotide polymorphism (SNP). The replication cohort was genotyped using TaqMan assay. The GWAS association analysis identified three potential SNPs rs118129027 (p-value = 6.24 × 10

DOI

10.1002/ajmg.b.32708

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