Document Type

Journal Article

Publication Title

The British Journal of Nutrition

ISSN

1475-2662

Volume

121

Issue

2

First Page

182

Last Page

194

PubMed ID

30430957

Publisher

Cambridge University Press

School

School of Medical and Health Sciences

RAS ID

28858

Comments

This article has been published in a revised form as: Woodman, R. J., Baghdadi, L. R., Shanahan, E. M., De Silva, I., Hodgson, J. M., & Mangoni, A. A. (2019). Diets high in n-3 fatty acids are associated with lower arterial stiffness in patients with rheumatoid arthritis: A latent profile analysis. British Journal of Nutrition, 121(2), 182-194. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © Cambridge University Press. Original article available here

Abstract

Supplementation with n-3 fatty acids can influence inflammation and markers of arterial stiffness that are increased in patients with rheumatoid arthritis (RA). However, it is unknown whether specific patterns of dietary fatty acid intake are similarly associated. In a longitudinal study, eighty-six RA patients reported their dietary intake and had arterial stiffness measured using the augmentation index (AIx) at baseline and 8 months. Latent profile analysis (LPA) was performed to characterise patterns of fatty acid intake using sixteen major fatty acids. Models for two to six profiles were compared using the Akaike and Bayesian information criteria. Associations between AIx and the profiles were adjusted for age, sex, disease activity, fish oil supplementation, medications, physical activity and socio-economic status. LPA identified five distinct profiles. Profile 1 subjects (n 7) reported significantly higher intake of palmitoleic acid (16 : 1), arachidonic acid (20 : 4n-6), EPA (20 : 5n-3), DHA (22 : 6n-3) and docosapentaenoic acid (22 : 5n-3) (P

DOI

10.1017/S0007114518003100

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