Document Type

Journal Article

Publication Title

Research & Reviews: Neuroscience


Scholarly publishing


School of Medical and Health Sciences / Centre of Excellence for Alzheimer's Disease Research and Care




Martins, I.J. (2018). Inactivation of endoplasmic reticulum stress and the prevention of neurodegenerative diseases. Research & Reviews: Neuroscience, 2(2), 22-25. Available here


Biotherapeutics and nutritional therapy are essential for the treatment of endoplasmic reticulum (ER) stress in diabetes and neurodegenerative diseases. Oxidative stress and nutrient excess may induce ER stress associated with activation of the unfolded protein response and connected to cell death. The heat shock gene Sirtuin 1 (Sirt 1) is important to the heat shock response with amyloid beta aggregation associated with the induction of mitophagy and ER stress in neuron cells. Genomic medicine that activates nuclear Sirt 1 is essential for the prevention of mitochondrial apoptosis and ER stress. Inhibitors such as drugs, alcohol, excess caffeine and palmitic acid may override the therapeutic effects of Sirt 1 activators with relevance to ER stress associated cell life and death decisions.

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.