Title

Range of normal liver stiffness and factors associated with increased stiffness measurements in apparently healthy individuals

Document Type

Journal Article

Publication Title

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

ISSN

1542-7714

Volume

17

Issue

1

First Page

54

Last Page

64

PubMed ID

30196155

Publisher

W.B. Saunders for the American Gastroenterological Association

RAS ID

27662

Comments

Originally published as: Bazerbachi, F., Haffar, S., Wang, Z., Cabezas, J., Arias-Loste, M. T., Crespo, J., ... & Petta, S. (2019). Range of Normal Liver Stiffness and Factors Associated With Increased Stiffness Measurements in Apparently Healthy Individuals. Clinical Gastroenterology and Hepatology, 17(1), 54-64. Original article available here

Abstract

BACKGROUND & AIMS: Transient elastography (TE) is a noninvasive technique used to measure liver stiffness to estimate the severity of fibrosis. The range of liver stiffness measurements (LSMs) in healthy individuals is unclear. We performed a systematic review to determine the range of LSMs, examined by TE, in healthy individuals and individuals who are susceptible to fibrosis.

METHODS: We collected data from 16,082 individuals, in 26 cohorts, identified from systematic searches of Embase, Ovid MEDLINE, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews for studies of liver stiffness measurements. Studies analyzed included apparently healthy adults (normal levels of liver enzymes, low-risk alcohol use patterns, and negative for markers of viral hepatitis). The presence of diabetes, hypertension, dyslipidemia, or steatosis, based on ultrasound examination, was known for most participants. We performed a meta-analysis of data from individual participants. The cohort was divided into 4 groups; participants with a body mass index/m

RESULTS: We established LSM ranges for healthy individuals measured with both probes-these did not change significantly in sensitivity analyses of individuals with platelets ≥150,000/mm

CONCLUSIONS: In a systematic review and meta-analysis of data from individual participants, we established a comprehensive set of LSM ranges, measured by TE in large cohorts of healthy individuals and persons susceptible to hepatic fibrosis. Regression analyses identified factors associated with increased LSMs obtained by TE with the medium and extra-large probes.

DOI

10.1016/j.cgh.2018.08.069

Access Rights

free_to_read

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