Title

Advances in pathological diagnosis of mesothelioma: What pulmonologists should know

Document Type

Journal Article

Publication Title

Current Opinion in Pulmonary Medicine

ISSN

1531-6971

Volume

25

Issue

4

First Page

354

Last Page

361

PubMed ID

31169558

Publisher

Lippincott Williams & Wilkins

School

School of Medical and Health Sciences

Comments

Originally published as: Louw, A., Badiei, A., Creaney, J., Chai, M. S., & Lee, Y. G. (2019). Advances in pathological diagnosis of mesothelioma: What pulmonologists should know. Current Opinion in Pulmonary Medicine, 25(4), 354-361. Original publication available here

Abstract

PURPOSE OF REVIEW: Malignant pleural mesothelioma (MPM) is a universally fatal illness with a rising incidence, particularly in developing countries. The diagnosis can be challenging and require repeated investigations with implications for the patient and healthcare system.

RECENT FINDINGS: Distinguishing between benign/reactive and malignant mesothelial proliferations can be challenging. Cytological diagnosis of MPM from pleural fluid is as reliable as histological analysis of tissue biopsies in epithelioid MPM - an approach endorsed by the International Academy of Cytology. Identification of BRCA1-associated protein 1 (BAP1) and cyclin-dependent kinase inhibitor 2A (CDKN2A) gene mutations in MPM have led to the development of new ancillary tests that can streamline the diagnostic pathway. The prognostic values of these molecules are being investigated. Clinicians should be aware of the recently described BAP1 tumor predisposition syndrome and offer genetic investigations in potential patients. Routine use of prophylactic radiotherapy in MPM patients after pleural interventions has been disproved in a randomized trial.

SUMMARY: Diagnosis of epithelioid MPM can be established on pleural fluid analysis in most patients. The use of BAP1 immunostaining and CDKN2A/p16 fluorescence in-situ hybridization are particularly useful in distinguishing benign from malignant mesothelial proliferations. Clinicians should ensure these investigations are available in the pathological assessment of cases to minimize invasive investigations and the associated risks.

DOI

10.1097/MCP.0000000000000578

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