Title

Low vitamin D status is associated with impaired bone quality and increased risk of fracture-related hospitalization in older Australian women

Document Type

Journal Article

Publication Title

Journal of Bone and Mineral Research

ISSN

1523-4681

PubMed ID

31233633

Publisher

American Society for Bone and Mineral Research

School

School of Medical and Health Sciences

RAS ID

28797

Grant Number

NHMRC Number : 1107474

Comments

Originally published as: Zhu, K., Lewis, J. R., Sim, M., & Prince, R. L. (2019). Low vitamin D status is associated with impaired bone quality and increased risk of fracture‐related hospitalization in older Australian women. Journal of Bone and Mineral Research. Advance online publication. Original publication available here

Abstract

The vitamin D debate relates in part to ideal public health population levels of circulating 25-hydroxyvitamin D (25OHD) to maintain bone structure and reduce fracture. In a secondary analysis of 1,348 women aged 70-85 years at baseline (1998) from the Perth Longitudinal Study of Aging in Women (PLSAW, a five-year calcium supplementation trial followed by two five-year extensions), we examined the dose-response relations of baseline plasma 25OHD with hip DXA BMD at year 1, lumbar spine BMD and trabecular bone score (TBS) at year 5, and fracture-related hospitalizations over 14.5 years obtained by health record linkage. Mean baseline plasma 25OHD was 66.9±28.2 nmol/L and 28.5%, 36.4% and 35.1% of women had levels50 nmol/L are a minimum public health target and 25OHD levels beyond 75 nmol/L may not have additional benefit to reduce fracture risk.

DOI

10.1002/jbmr.3818

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