Title

Low vitamin D status is associated with impaired bone quality and increased risk of fracture-related hospitalization in older Australian women

Authors

Kun Zhu
Joshua R. Lewis, Edith Cowan UniversityFollow
Marc Sim, Edith Cowan UniversityFollow
Richard L. Prince

Author Identifier

Marc Sim Orcid: https://orcid.org/0000-0001-5166-0605

Document Type

Journal Article

Publication Title

Journal of Bone and Mineral Research

ISSN

1523-4681

PubMed ID

31233633

Publisher

American Society for Bone and Mineral Research

School

School of Medical and Health Sciences

RAS ID

28797

Grant Number

NHMRC Number : 1107474

Grant Link

http://purl.org/au-research/grants/nhmrc/1107474

Comments

This is an Author's Accepted Manuscript of Zhu, K., Lewis, J. R., Sim, M., & Prince, R. L. (2019). Low vitamin D status is associated with impaired bone quality and increased risk of fracture‐related hospitalization in older Australian women. Journal of Bone and Mineral Research. 34 (11) 2019-2027.

Available here

Abstract

The vitamin D debate relates in part to ideal public health population levels of circulating 25-hydroxyvitamin D (25OHD) to maintain bone structure and reduce fracture. In a secondary analysis of 1,348 women aged 70-85 years at baseline (1998) from the Perth Longitudinal Study of Aging in Women (PLSAW, a five-year calcium supplementation trial followed by two five-year extensions), we examined the dose-response relations of baseline plasma 25OHD with hip DXA BMD at year 1, lumbar spine BMD and trabecular bone score (TBS) at year 5, and fracture-related hospitalizations over 14.5 years obtained by health record linkage. Mean baseline plasma 25OHD was 66.9±28.2 nmol/L and 28.5%, 36.4% and 35.1% of women had levels50 nmol/L are a minimum public health target and 25OHD levels beyond 75 nmol/L may not have additional benefit to reduce fracture risk.

DOI

10.1002/jbmr.3818