Author Identifier
Marc Sim Orcid: https://orcid.org/0000-0001-5166-0605
Document Type
Journal Article
Publication Title
Journal of Bone and Mineral Research
ISSN
1523-4681
PubMed ID
31233633
Publisher
American Society for Bone and Mineral Research
School
School of Medical and Health Sciences
RAS ID
28797
Grant Number
NHMRC Number : 1107474
Abstract
The vitamin D debate relates in part to ideal public health population levels of circulating 25-hydroxyvitamin D (25OHD) to maintain bone structure and reduce fracture. In a secondary analysis of 1,348 women aged 70-85 years at baseline (1998) from the Perth Longitudinal Study of Aging in Women (PLSAW, a five-year calcium supplementation trial followed by two five-year extensions), we examined the dose-response relations of baseline plasma 25OHD with hip DXA BMD at year 1, lumbar spine BMD and trabecular bone score (TBS) at year 5, and fracture-related hospitalizations over 14.5 years obtained by health record linkage. Mean baseline plasma 25OHD was 66.9±28.2 nmol/L and 28.5%, 36.4% and 35.1% of women had levels50 nmol/L are a minimum public health target and 25OHD levels beyond 75 nmol/L may not have additional benefit to reduce fracture risk.
DOI
10.1002/jbmr.3818
Research Themes
Health
Priority Areas
Exercise, nutrition, lifestyle and other interventions for optimal health across the lifespan
Comments
This is an Author's Accepted Manuscript of Zhu, K., Lewis, J. R., Sim, M., & Prince, R. L. (2019). Low vitamin D status is associated with impaired bone quality and increased risk of fracture‐related hospitalization in older Australian women. Journal of Bone and Mineral Research. 34 (11) 2019-2027.
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