Nicola P. Bondonno, Edith Cowan UniversityFollow
Catherine P. Bondonno, Edith Cowan UniversityFollow
Joshua R. Lewis, Edith Cowan UniversityFollow
Kevin D. Croft
Jonathan M. Hodgson, Edith Cowan UniversityFollow
Nicola Bondonno Orcid: https://orcid.org/0000-0001-5905-444X Catherine Bondonno Orcid: https://orcid.org/0000-0001-8509-439X Jonathan Hodgson Orcid: https://orcid.org/0000-0001-6184-7764
School of Medical and Health Sciences
Danish Cancer Society, Denmark; The Danish Heart Foundation (Grant number 17-R115-A7443-22062; Gangstedfonden (Grant number A35136), Denmark; National Health and Medical Research Council Early Career Fellowship (Grant number APP1159914), Australia; National Health and Medical Research Council of Australia Senior Research Fellowship, Australia (Grant number APP1116937).
NHMRC Number : GNT1159914, NHMRC Number : 1116973
Flavonoids, plant-derived polyphenolic compounds, have been linked with health benefits. However, evidence from observational studies is incomplete; studies on cancer mortality are scarce and moderating effects of lifestyle risk factors for early mortality are unknown. In this prospective cohort study including 56,048 participants of the Danish Diet, Cancer, and Health cohort crosslinked with Danish nationwide registries and followed for 23 years, there are 14,083 deaths. A moderate habitual intake of flavonoids is inversely associated with all-cause, cardiovascular- and cancer-related mortality. This strong association plateaus at intakes of approximately 500 mg/day. Furthermore, the inverse associations between total flavonoid intake and mortality outcomes are stronger and more linear in smokers than in non-smokers, as well as in heavy (>20 g/d) vs. low-moderate (/d) alcohol consumers. These findings highlight the potential to reduce mortality through recommendations to increase intakes of flavonoid-rich foods, particularly in smokers and high alcohol consumers.
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