The Han Chinese population and genetic susceptibility to type 2 diabetes: Potential role for variants in SUMO4 gene
Medicine and Biopharmaceutical: Proceedings of the 2015 International Conference
School of Medical and Health Sciences / Systems and Intervention Research Centre for Health
SUMO4 gene is located on chromosome 6q25, and a single nucleotide polymorphism (SNP) is associated with susceptibility to type 1 diabetes. Type 1 and type 2 diabetes have familial clustering, which suggests a common genetic basis between them. Several susceptibility genes have been reported to associate with both of them. This study aimed to detect the potential association of SUMO4 gene polymorphisms with susceptibility to T2DM by a case-control study of north Chinese population. 100 patients with T2DM were included in this study and 500 controls. The 4 SNPs in SUMO4 gene were genotyped by polymerase chain reaction-high resolution melting curve (PCRHRM). The relationship of allelic and genotypic frequencies of the SUMO4 gene with the risk of T2DM was evaluated by the crude and adjusted odds ratios (ORs) with their 95% confidence intervals (CIs) from multivariate logistic regression models. Then we reviewed the association between rs237025 and T2DM in Asian populations via a meta-analysis. The logistic regression analysis adjusted by gender and age showed significant association for rs17506789 GG+GA genotype (OR=1.831, P=0.032). However, no association was observed for rs237025 in our sample. We identified five other studies for rs237025 (2562 T2DM patients and 2509 controls) in Asian. Meta-analysis indicated significant associations for the rs237025 G allele (OR=1.15, 95% CI =1.05– 1.25, P=0.002). Subjects having haplotype AAC were more susceptible to T2DM in the Chinese population (OR=1.5, P=0.02). SNPs rs17506789 and rs237025 are associated with susceptibility to T2DM, and haplotype AAC also contributes to the development of T2DM.