Author Identifier

Deirdre Collins

Thomas Riley

Document Type

Journal Article

Publication Title

Expert Review of Anti-Infective Therapy


Taylor and Francis


School of Medical and Health Sciences




National Health and Medical Research Council.

Australia Africa University Network.

Further funding information available at:

Grant Number

NHMRC Numbers : 1138257, GNT1156789


This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Anti-infective Therapy on 6 December 2019, available online:

Imwattana, K., Knight, D. R., Kullin, B., Collins, D. A., Putsathit, P., Kiratisin, P., & Riley, T. V. (2020). Antimicrobial resistance in Clostridium difficile ribotype 017. Expert Review of Anti-infective Therapy, 18(1), 17-25.



Antimicrobial resistance (AMR) played an important role in the initial outbreaks of Clostridium difficile infection (CDI) in the 1970s. C. difficile ribotype (RT) 017 has emerged as the major strain of C. difficile in Asia, where antimicrobial use is poorly regulated. This strain has also caused CDI outbreaks around the world for almost 30 years. Many of these outbreaks were associated with clindamycin and fluoroquinolone resistance. AMR and selective pressure is likely to be responsible for the success of this RT and may drive future outbreaks.

Areas covered:

This narrative journalarticle summarizes the prevalence and mechanisms of AMR in C. difficile RT 017 and transmission of these AMR mechanisms. To address these topics, reports of outbreaks due to C. difficile RT 017, epidemiologic studies with antimicrobial susceptibility results, studies on resistance mechanisms found in C. difficile and related publications available through Pubmed until September 2019 were collated and the findings discussed.

Expert opinion:

Primary prevention is the key to control CDI. This should be achieved by developing antimicrobial stewardship in medical, veterinary and agricultural practices. AMR is the key factor that drives CDI outbreaks, and methods for the early detection of AMR can facilitate the control of outbreaks.