Preimplantation genetic testing: Changes in biopsy technique and clinical utility
Journal of Reproductive Biotechnology and Fertility
JRBF Online Publications
School of Medical and Health Sciences
The last forty years has seen vast changes in the way embryos are assessed and selected for use in Assisted reproductive technology (ART) procedures. The introduction of preimplantation genetic testing (PGT) produced a new means to do this but also caused ethical, legal and practical concerns. This review aims to identify how the type and quality of genetic testing available has changed over time, review how legislation governing PGT differs worldwide and identify the ethical issues that have emerged. It examines how the type of cell collection biopsy has evolved and discusses what this means with regard to clinical outcomes and future practice. PGT use has seen improvement to implantation rates and clinical pregnancies, reductions in miscarriage rates and quicker cumulative pregnancy rates. Issues of cost-effectiveness remain the next challenge to overcome.