Preimplantation genetic testing: Changes in biopsy technique and clinical utility

Document Type

Journal Article

Publication Title

Journal of Reproductive Biotechnology and Fertility

Publisher

JRBF Online Publications

School

School of Medical and Health Sciences

RAS ID

30289

Comments

Scott, J., Roberts, P., Matson, P. (2019). Preimplantation genetic testing: Changes in biopsy technique and clinical utility. Journal of Reproductive Biotechnology and Fertility, 8, 54-65. https://www.ivf-hub.net/journal-archive-new/2019-2/

Abstract

The last forty years has seen vast changes in the way embryos are assessed and selected for use in Assisted reproductive technology (ART) procedures. The introduction of preimplantation genetic testing (PGT) produced a new means to do this but also caused ethical, legal and practical concerns. This review aims to identify how the type and quality of genetic testing available has changed over time, review how legislation governing PGT differs worldwide and identify the ethical issues that have emerged. It examines how the type of cell collection biopsy has evolved and discusses what this means with regard to clinical outcomes and future practice. PGT use has seen improvement to implantation rates and clinical pregnancies, reductions in miscarriage rates and quicker cumulative pregnancy rates. Issues of cost-effectiveness remain the next challenge to overcome.

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