Author Identifier

Syed Zulqarnain Gilani

Orcid: https://orcid.org/0000-0002-7448-2327

David Suter

https://orcid.org/0000-0001-6306-3023

Document Type

Journal Article

Publication Title

Translational Psychiatry

Publisher

Springer Nature

School

School of Science

RAS ID

30510

Grant Number

NHMRC Number : APP1077966

Comments

Tan, D. W., Maybery, M. T., Gilani, S. Z., Alvares, G. A., Mian, A., Suter, D., & Whitehouse, A. J. O. (2020). A broad autism phenotype expressed in facial morphology. Translational Psychiatry, 10(1). https://doi.org/10.1038/s41398-020-0695-z

Abstract

Autism spectrum disorder is a heritable neurodevelopmental condition diagnosed based on social and communication differences. There is strong evidence that cognitive and behavioural changes associated with clinical autism aggregate with biological relatives but in milder form, commonly referred to as the ‘broad autism phenotype’. The present study builds on our previous findings of increased facial masculinity in autistic children (Sci. Rep., 7:9348, 2017) by examining whether facial masculinity represents as a broad autism phenotype in 55 non-autistic siblings (25 girls) of autistic children. Using 3D facial photogrammetry and age-matched control groups of children without a family history of ASD, we found that facial features of male siblings were more masculine than those of male controls (n = 69; p < 0.001, d = 0.81 [0.36, 1.26]). Facial features of female siblings were also more masculine than the features of female controls (n = 60; p = 0.005, d = 0.63 [0.16, 1.10]). Overall, we demonstrated for males and females that facial masculinity in non-autistic siblings is increased compared to same-sex comparison groups. These data provide the first evidence for a broad autism phenotype expressed in a physical characteristic, which has wider implications for our understanding of the interplay between physical and cognitive development in humans.

DOI

10.1038/s41398-020-0695-z

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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