Author Identifier

Pratishtha Chatterjee

Orcid: https://orcid.org/0000-0003-4877-1958

Tejal Shah

Orcid: https://orcid.org/0000-0002-3069-3835

Hamid Sohrabi

Orcid: https://orcid.org/0000-0001-8017-8682

Steve Pedrini

Orcid: https://orcid.org/0000-0002-6409-8022

Ralph Martins

Orcid: https://orcid.org/0000-0002-4828-9363

Document Type

Journal Article

Publication Title

Journal of Alzheimer’s Disease

Publisher

IOS Press

School

School of Medical Health and Sciences

Funders

Edith Cowan University - Open Access Support Scheme

Comments

Chatterjee, P., Mohammadi, M., Goozee, K., Shah, T. M., Sohrabi, H. R., Dias, C. B., ... & Ashton, N. J. (2020). Serum Hepcidin Levels in Cognitively Normal Older Adults with High Neocortical Amyloid-β Load. Journal of Alzheimer's Disease, 76(1), 291-301. https://doi.org/10.3233/JAD-200162

Abstract

Background/Objective:

Hepcidin, an iron-regulating hormone, suppresses the release of iron by binding to the iron exporter protein, ferroportin, resulting in intracellular iron accumulation. Given that iron dyshomeostasis has been observed in Alzheimer’s disease (AD) together with elevated serum hepcidin levels, the current study examined whether elevated serum hepcidin levels are an early event in AD pathogenesis by measuring the hormone in cognitively normal older adults at risk of AD, based on high neocortical amyloid-β load (NAL).

Methods:

Serum hepcidin levels in cognitively normal participants (n = 100) aged between 65–90 years were measured using ELISA. To evaluate NAL, all participants underwent 18F-florbetaben positron emission tomography. A standard uptake value ratio (SUVR) < 1.35 was classified as low NAL (n = 65) and ≥ 1.35 (n = 35) was classified as high NAL.

Results:

Serum hepcidin was significantly higher in participants with high NAL compared to those with low NAL before and after adjusting for covariates: age, gender, and APOE ɛ4 carriage (p  <  0.05). A receiver operating characteristic curve based on a logistic regression of the same covariates, the base model, distinguished high from low NAL (area under the curve, AUC  =  0.766), but was outperformed when serum hepcidin was added to the base model (AUC = 0.794) and further improved with plasma Aβ42/40 ratio (AUC = 0.829).

Conclusion:

The present findings indicate that serum hepcidin is increased in individuals at risk for AD and contribute to the body of evidence supporting iron dyshomeostasis as an early event of AD. Further, hepcidin may add value to a panel of markers that contribute toward identifying individuals at risk of AD; however, further validation studies are required.

DOI

10.3233/JAD-200162

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

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