Wei Ling Florence Lim, Edith Cowan UniversityFollow
Pratishtha Chatterjee, Edith Cowan UniversityFollow
Kaushala S. Jayawardana
Natalie A. Mellett
Simon M. Laws, Edith Cowan UniversityFollow
Ashley I. Bush
Christopher C. Rowe
Victor L. Villemagne
Brian G. Drew
Colin L. Masters
Peter J. Meikle
Ralph Martins, Edith Cowan UniversityFollow
Australian Imaging, Biomarker & Lifestyle research group
Wei Ling Florence Lim
Simon M. Laws
Ralph N. Martins
Journal of Alzheimer’s Disease
School of Medical and Health Sciences / Collaborative Genomics Group
Edith Cowan University - Open Access Support Scheme 2020
Lipid metabolism is altered in Alzheimer’s disease (AD); however, the relationship between AD risk factors (age, APOE ɛ4, and gender) and lipid metabolism is not well defined.
We investigated whether altered lipid metabolism associated with increased age, gender, and APOE status may contribute to the development of AD by examining these risk factors in healthy controls and also clinically diagnosed AD individuals.
We performed plasma lipidomic profiling (582 lipid species) of the Australian Imaging, Biomarkers and Lifestyle flagship study of aging cohort (AIBL) using liquid chromatography-mass spectrometry. Linear regression and interaction analysis were used to explore the relationship between risk factors and plasma lipid species.
We observed strong associations between plasma lipid species with gender and increasing age in cognitively normal individuals. However, APOE ɛ4 was relatively weakly associated with plasma lipid species. Interaction analysis identified differential associations of sphingolipids and polyunsaturated fatty acid esterified lipid species with AD based on age and gender, respectively. These data indicate that the risk associated with age, gender, and APOE ɛ4 may, in part, be mediated by changes in lipid metabolism.
This study extends our existing knowledge of the relationship between the lipidome and AD and highlights the complexity of the relationships between lipid metabolism and AD at different ages and between men and women. This has important implications for how we assess AD risk and also for potential therapeutic strategies involving modulation of lipid metabolic pathways.
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