Author Identifier

Oliver Schumacher

Orcid: https://orcid.org/0000-0002-8814-9429

Daniel Galvao

Orcid: https://orcid.org/0000-0002-8209-2281

Dennis Taaffe

Orcid: https://orcid.org/0000-0001-6381-1597

Robert Newton

Orcid: https://orcid.org/0000-0003-0302-6129

Document Type

Journal Article

Publication Title

Prostate Cancer and Prostatic Diseases

Publisher

Springer Nature

School

Exercise Medicine Research Institute / School of Medical and Health Sciences

Funders

Edith Cowan University - Open Access Support Scheme

Comments

Schumacher, O., Galvão, D.A., Taaffe, D.R., Chee, R., Spry, N., & Newton, R. (2020). Exercise modulation of tumour perfusion and hypoxia to improve radiotherapy response in prostate cancer. Prostate Cancer and Prostatic Diseases, Advanced online publication.

https://doi.org/10.1038/s41391-020-0245-z

Abstract

Background

An increasing number of studies indicate that exercise plays an important role in the overall care of prostate cancer (PCa) patients before, during and after treatment. Historically, research has focused on exercise as a modulator of physical function, psychosocial well-being as well as a countermeasure to cancer- and treatment-related adverse effects. However, recent studies reveal that exercise may also directly influence tumour physiology that could beneficially affect the response to radiotherapy.

Methods

In this narrative review, we provide an overview of tumour vascular characteristics that limit the effect of radiation and establish a rationale for exercise as adjunct therapy during PCa radiotherapy. Further, we summarise the existing literature on exercise as a modulator of tumour perfusion and hypoxia and outline potential future research directions.

Results

Preclinical research has shown that exercise can reduce intratumoral hypoxia—a major limiting factor in radiotherapy—by improving tumour perfusion and vascularisation. In addition, preliminary evidence suggests that exercise training can improve radiotherapy treatment outcomes by increasing natural killer cell infiltration in a murine PCa model.

Conclusions

Exercise is a potentially promising adjunct therapy for men with PCa undergoing radiotherapy that may increase its effectiveness. However, exercise-induced tumour radiosensitisation remains to be confirmed in preclinical and clinical trials, as does the optimal exercise prescription to elicit such effects.

DOI

10.1038/s41391-020-0245-z

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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