Document Type

Journal Article

Publication Title

Clinical Nutrition




School of Medical and Health Sciences




The Danish Diet, Cancer, and Health Study was funded by the Danish Cancer Society, Denmark. FD is funded by The Danish Heart Foundation (Grant number 17-R115-A7443-22062) and Gangstedfonden (Grant number A35136), Denmark. NPB is funded by a National Health and Medical Research Council Early Career Fellowship (Grant number APP1159914), Australia. The salary of JMH is supported by a National Health and Medical Research Council of Australia Senior Research Fellowship, Australia (Grant number APP1116937). CK is funded by the Danish Cancer Society (Knæk Cancer 2017, Grant number R174-A11507-17-S52).

Grant Number

NHMRC Number : APP1116937


Bondonno, N. P., Murray, K., Bondonno, C. P., Lewis, J. R., Croft, K. D., Kyrø, C., ... & Piccini, J. P. (2020). Flavonoid intake and its association with atrial fibrillation. Clinical Nutrition, 30(12), 3821-3828.


Background & aims: Primary prevention of atrial fibrillation (AF) through behavioural and dietary modification is a critically important and unmet need. Flavonoids are bioactive dietary compounds with promising cardiovascular health benefits. Our aim was to investigate the association between flavonoid intake and clinically apparent AF. Methods: Baseline data from 55 613 participants of the Danish Diet, Cancer and Health Study, without AF, recruited between 1993 and 1997, were cross-linked with Danish nationwide registries. Total flavonoid and flavonoid subclass intakes were calculated from validated food frequency questionnaires using the Phenol-Explorer database. Associations between flavonoid intake and incident AF (first-time hospitalization or outpatient visit) were examined using restricted cubic splines based on Cox proportional hazards models. Results: During a median [IQR] follow-up of 21 [18–22] years, 7291 participants were diagnosed with AF. Total flavonoid intake was not statistically significantly associated with risk of incident AF in the whole cohort. However, compared to the lowest quintile, a total flavonoid intake of 1000 mg/day was associated with a lower risk of AF in smokers [0.86 (0.77, 0.96)] but not in non-smokers [0.96 (0.88, 1.06)], and a lower risk of AF in high alcohol consumers [ > 20 g/d: 0.84 (0.75, 0.95)] but not in low-to-moderate alcohol consumers [ < 20 g/d: 0.97 (0.89, 1.07)]. Conclusion: Intake of flavonoids was not significantly associated with a lower risk of incident AF. However, higher intakes of flavonoids may be beneficial for those at a higher risk of developing AF.



Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.