Author Identifier
Travis Cruickshank
https://orcid.org/0000-0001-8673-191X
Tim Rankin
https://orcid.org/0000-0002-2915-3460
Danielle Bartlett
https://orcid.org/0000-0002-6096-3760
Anthony Blazevich
https://orcid.org/0000-0003-1664-1614
Mel Ziman
Document Type
Journal Article
Publication Title
Scientific Reports
Publisher
Nature
School
School of Medical and Health Sciences / Exercise Medicine Research Institute
RAS ID
32271
Funders
Edith Cowan University - Open Access Support Scheme 2020
Abstract
The aim of the present study was to quantify explosive joint torque or the ability to develop joint torque rapidly, typically measured as the rate of torque development, in individuals with prodromal Huntington’s disease and healthy controls and its associations with measures of disease burden and striatal pathology. Twenty prodromal Huntington’s disease and 19 healthy control individuals volunteered for this study. Plantar flexor isometric rate of torque development values were evaluated using isokinetic dynamometry. Pathological changes in striatal shape were evaluated using magnetic resonance imaging. Disease burden was evaluated using the disease burden score and cytosine-adenine-guanine age product score. No statistical differences in the rate of torque development were observed between individuals with prodromal Huntington’s disease and healthy controls. However, significant associations were observed between the rate of torque development values and measures of disease burden (r = −0.42 to −0.69) and striatal pathology (r = 0.71–0.60) in individuals with prodromal Huntington’s disease. We found significant associations between lower rate of torque development values and greater striatal shape deflation and disease burden and striatal pathology in individuals with prodromal Huntington’s disease. While no significant differences in the rate of torque development were found between prodromal Huntington’s disease and healthy controls, the noted associations suggest that differences may emerge as the disease advances, which should be investigated longitudinally in future studies.
DOI
10.1038/s41598-020-72042-2
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Cruickshank, T., Reyes, A., Pulverenti, T.S., Rankin, T. Bartlett, D., Blazevich, A., ... & Trajano, G. (2020). Rate of torque development and striatal shape in individuals with prodromal Huntington's disease. Scientific Reports, 10, Article 15103. https://doi.org/10.1038/s41598-020-72042-2