Author Identifier
Lokeswari P. Tangella
https://orcid.org/0000-0002-1293-3348
Michael E. Clark
https://orcid.org/0000-0002-9748-5221
Elin S. Gray
Document Type
Journal Article
Publication Title
Biochimica et Biophysica Acta
Publisher
Elsevier
School
School of Medical and Health Sciences
RAS ID
32397
Funders
Edith Cowan University - Open Access Support Scheme 2020
Abstract
Background
The introduction of targeted therapies for the treatment of BRAF-mutant melanomas have improved survival rates in a significant proportion of patients. Nonetheless, the emergence of resistance to treatment remains inevitable in most patients.
Scope of review
Here, we review known and emerging molecular mechanisms that underlay the development of resistance to MAPK inhibition in melanoma cells and the potential strategies to overcome these mechanisms.
Major conclusions
Multiple genetic and non-genetic mechanisms contribute to treatment failure, commonly leading to the reactivation of the MAPK pathway. A variety of resistance mechanisms are enabled by the underlying heterogeneity and plasticity of melanoma cells. Moreover, it has become apparent that resistance to targeted therapy is underpinned by early functional adaptations involving the rewiring of cell states and metabolic pathways.
General significance
The evidence presented suggest that the use of a combinatorial treatment approach would delay the emergence of resistance and improve patient outcomes.
DOI
10.1016/j.bbagen.2020.129736
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Comments
Tangella, L. P., Clark, M. E., & Gray, E. S. (2020). Resistance mechanisms to targeted therapy in BRAF-mutant melanoma-A mini review. Biochimica et Biophysica Acta (BBA)-General Subjects, 1865, Article 129736. https://doi.org/10.1016/j.bbagen.2020.129736