Title

Comorbidity of cerebrovascular and Alzheimer's disease in aging

Document Type

Journal Article

Publication Title

Journal of Alzheimer's Disease

ISSN

13872877

Volume

78

Issue

1

First Page

321

Last Page

334

Publisher

IOS Press

School

School of Medical and Health Sciences

RAS ID

32290

Funders

Funding information available at: https://content.iospress.com/articles/journal-of-alzheimers-disease/jad200419

Comments

Xia, Y., Yassi, N., Raniga, P., Bourgeat, P., Desmond, P., Doecke, J., ... Salvado, O. (2020). Comorbidity of cerebrovascular and Alzheimer’s disease in aging. Journal of Alzheimer's Disease, 78(1), 321-334. https://doi.org/10.3233/JAD-200419

Abstract

© 2020 - IOS Press and the authors. All rights reserved. Background: Cerebrovascular disease often coexists with Alzheimer's disease (AD). While both diseases share common risk factors, their interrelationship remains unclear. Increasing the understanding of how cerebrovascular changes interact with AD is essential to develop therapeutic strategies and refine biomarkers for early diagnosis. Objective: We investigate the prevalence and risk factors for the comorbidity of amyloid-ß (Aß) and cerebrovascular disease in the Australian Imaging, Biomarkers and Lifestyle Study of Ageing, and further examine their cross-sectional association. Methods: A total of 598 participants (422 cognitively normal, 89 with mild cognitive impairment, 87 with AD) underwent positron emission tomography and structural magnetic resonance imaging for assessment of Aß deposition and cerebrovascular disease. Individuals were categorized based on the comorbidity status of Aß and cerebrovascular disease (V) as Aß-V-, Aß-V+, Aß+V-, or Aß+V+. Results: Advancing age was associated with greater likelihood of cerebrovascular disease, high Aß load and their comorbidity. Apolipoprotein E ɛ4 carriage was only associated with Aß positivity. Greater total and regional WMH burden were observed in participants with AD. However, no association were observed between Aß and WMH measures after stratification by clinical classification, suggesting that the observed association between AD and cerebrovascular disease was driven by the common risk factor of age. Conclusion: Our observations demonstrate common comorbid condition of Aß and cerebrovascular disease in later life. While our study did not demonstrate a convincing cross-sectional association between Aß and WMH burden, future longitudinal studies are required to further confirm this.

DOI

10.3233/JAD-200419

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