Document Type

Journal Article

Publication Title

Scandinavian Journal of Rheumatology

ISSN

03009742

Publisher

Taylor and Francis

School

School of Medical and Health Sciences

RAS ID

32194

Comments

This is an Accepted Manuscript of an article published by Taylor & Francis in SCANDINAVIAN JOURNAL OF RHEUMATOLOGY on 18/09/2020, available online: http://www.tandfonline.com/10.1080/03009742.2020.1800081

Rehman, A., Carroll, G. J., Powell, L. W., Ramm, L. E., Ramm, G. A., & Olynyk, J. K. (2020). Arthropathy in hereditary haemochromatosis segregates with elevated erythrocyte mean corpuscular volume. Scandinavian Journal of Rheumatology. Advance online publication. https://doi.org/10.1080/03009742.2020.1800081

Abstract

© 2020 Informa Healthcare on license from Scandinavian Rheumatology Research Foundation. Objective: To evaluate the relationship between erythrocyte parameters and the presence or absence of arthritis in HFE C282Y homozygous hereditary haemochromatosis (HH) subjects compared to control groups of non-HH subjects with arthritis. Method: Erythrocyte and arthritis parameters [mean corpuscular volume (MCV) and mean cell haemoglobin (MCH)] were obtained from consecutive HH subjects (n = 119) who were referred for initial evaluation and management. For comparison, MCV and MCH values were collected from randomly selected non-HH subjects with rheumatoid arthritis (n = 100) and osteoarthritis (n = 100), consisting of equal numbers of men and women. Two other comparison groups comprised 16 men and women who were heterozygous for C282Y with arthritis, and 38 non-HH subjects with type 2 polyarticular osteoarthritis (T2POA). Results: MCV values were significantly higher in HH subjects with arthritis (95 ± 0.56 fL) than in HH subjects without arthritis (92.75 ± 0.50 fL, p = 0.037). HH subjects with or without arthritis demonstrated a higher mean MCV than the control groups of non-HH osteoarthritis (90.12 ± 0.46 fL, p < 0.001) and non-HH rheumatoid arthritis (90.94 ± 0.57 fL, p < 0.001). HH subjects with arthritis also demonstrated a higher MCV than heterozygous C282Y subjects with arthritis (93.18 ± 1.55 fL, p = 0.025) and non-HH subjects with a similar pattern of arthritis, notably T2POA (91.13 ± 0.50 fL, p < 0.01). An MCV of ≥ 97.85 fL provided a likelihood ratio of 2.2 for development of arthritis in HH subjects. Conclusion: This study demonstrated a relationship between elevated MCV and arthritis in incident cases of HH.

DOI

10.1080/03009742.2020.1800081

Available for download on Saturday, September 18, 2021

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