Title

Identifying preventable risk factors for hospitalised asthma in young Aboriginal children: A whole-population cohort study

Document Type

Journal Article

Publication Title

Thorax

Publisher

BMJ Publishing Group

School

Kurongkurl Katitjin

Funders

National Health and Medical Research Council of Australia

Grant Number

NHMRC Number : 1078214, 1135273

Grant Link

http://purl.org/au-research/grants/nhmrc/1078214 http://purl.org/au-research/grants/nhmrc/1135273

Comments

Brew, B., Gibberd, A., Marks, G. B., Strobel, N., Allen, C. W., Jorm, L., ... McNamara, B. (2021). Identifying preventable risk factors for hospitalised asthma in young Aboriginal children: A whole-population cohort study. Thorax. Advance online publication. https://doi.org/10.1136/thoraxjnl-2020-216189

Abstract

© 2021 Author(s) (or their employer(s)). No commercial re-use. See rights and permissions. Published by BMJ. Background: Australia has one of the highest rates of asthma worldwide. Indigenous children have a particularly high burden of risk determinants for asthma, yet little is known about the asthma risk profile in this population. Aim: To identify and quantify potentially preventable risk factors for hospitalised asthma in Australian Aboriginal children (1-4 years of age). Methods: Birth, hospital and emergency data for all Aboriginal children born 2003-2012 in Western Australia were linked (n=32 333). Asthma was identified from hospitalisation codes. ORs and population attributable fractions were calculated for maternal age at birth, remoteness, area-level disadvantage, prematurity, low birth weight, maternal smoking in pregnancy, mode of delivery, maternal trauma and hospitalisations for acute respiratory tract infection (ARTI) in the first year of life. Results: There were 705 (2.7%) children hospitalised at least once for asthma. Risk factors associated with asthma included: being hospitalised for an ARTI (OR 4.06, 95% CI 3.44 to 4.78), area-level disadvantage (OR 1.58, 95% CI 1.28 to 1.94), being born at < 33 weeks' gestation (OR 3.30, 95% CI 2.52 to 4.32) or birth weight < 1500 g (OR 2.35, 95% CI 1.39 to 3.99). The proportion of asthma attributable to an ARTI was 31%, area-level disadvantage 18%, maternal smoking 5%, and low gestational age and birth weight were 3%-7%. We did not observe a higher risk of asthma in those children who were from remote areas. Conclusion: Improving care for pregnant Aboriginal women as well as for Aboriginal infants with ARTI may help reduce the burden of asthma in the Indigenous population.

DOI

10.1136/thoraxjnl-2020-216189

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